Results 271 to 280 of about 115,534 (346)

Cell Proliferation and Chemical Carcinogenesis: Cell Proliferative Potential of Non-genotoxic or Genotoxic Hepatocarcinogens.

, 1995
Kunie Yoshikawa
openalex   +2 more sources

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

Aging Cell, EarlyView.
Cockayne Syndrome complementation group B (CS‐B) is a highly debilitating progeroid syndrome that often culminates in the death of patients before adulthood. This review explores the pathogenesis of CS‐B and proposes that a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction is its underlying cause ...
Ricardo Afonso‐Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega   +3 more
wiley   +1 more source

Genotoxic Effects of Chromium(III) and Cobalt(II) and Their Mixtures on the Selected Cell Lines. [PDF]

Int J Mol Sci
Czarnek K, Tatarczak-Michalewska M, Blicharska E, Siwicki AK, Maciejewski R.   +4 more
europepmc   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, EarlyView.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation. [PDF]

BMC Pharmacol Toxicol
Essa HA, Ali E, Zahraa Abd El Hakam FE, Akl EM.   +3 more
europepmc   +1 more source

Cell‐Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis

Aging Cell, EarlyView.
We have validated the selective upregulation of LAMP1 in SEN in culture, and the percentage of Lamp1+ cells increases in various tissues with age, as well as in fibrotic lungs following BLM instillation. The RNA‐Sequencing analysis of the Lamp1‐enriched populations confirmed the enrichment of senescence‐related genes.
Gabriel Meca‐Laguna, Michael Qiu, Yafei Hou, Anna Barkovskaya, Apoorva Shankar, Bhavna Dixit, Michael J. Rae, Amutha Boominathan, Amit Sharma   +8 more
wiley   +1 more source

Cytotoxicity and genotoxicity of orthodontic bands after aging: an in-vitro study. [PDF]

BMC Oral Health
Karandish M, Khademi B, Ziaei G, Erfani N, Moezi L, Faghih Z.   +5 more
europepmc   +1 more source

Genotoxic effects of alpha-endosulfan and beta-endosulfan on human HepG2 cells.

, 2000
Yuquan Lu, Kazuyoshi Morimoto, Tatsuya Takeshita, T Takeuchi, T. Saito   +4 more
openalex   +1 more source

Safety concerns of paternal drug exposure on fertility, pregnancy and offspring: An analysis based on the FDA adverse event reporting system

Andrology, EarlyView.
Abstract Background Growing evidence indicates that paternal condition significantly influences pregnancy outcomes and offspring health. However, assessing the safety of paternal drug exposure via randomized controlled trials poses ethical challenges, and relevant clinical studies consume a lot of resources to evaluate only a few drugs.
Yanbin Zeng, Wanlong Lin, Wei Zhuang
wiley   +1 more source

Toxicological assessment of omethoate insecticide in Allium cepa L. [PDF]

Sci Rep
Karagol S, Macar O, Çavuşoğlu K, Yalçın E.   +3 more
europepmc   +1 more source