Results 251 to 260 of about 56,006 (307)
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Chemical Research in Toxicology, 2023
Higher stress and anxiety levels are often reported globally. While anecdotal evidence has attributed a myriad of health conditions to stress, the mechanisms are often overlooked. Understanding the role of stress hormones on DNA damage/oxidative stress has implications for disease.
Renée L. Flaherty, Melanie S. Flint
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Higher stress and anxiety levels are often reported globally. While anecdotal evidence has attributed a myriad of health conditions to stress, the mechanisms are often overlooked. Understanding the role of stress hormones on DNA damage/oxidative stress has implications for disease.
Renée L. Flaherty, Melanie S. Flint
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Quantifying genotoxicity and non-genotoxicity
Mutation Research/Genetic Toxicology, 1988Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of ...
H S, Rosenkranz, F K, Ennever
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Current Drug Metabolism, 2018
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo +4 more
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With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo +4 more
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Genotoxicity of Streptozotocin
Mutation Research/Reviews in Mutation Research, 2002Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
C, Winder, T, Bonin
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Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
C, Winder, T, Bonin
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Parabens are being used as preservatives due to their antifungal and antimicrobial effects. They are emerging as aquatic pollutants due to their excessive use in many products. The purpose of this study was to determine the toxic effect of ethyl paraben (
Tetyana Kobets, A. Wallace Hayes
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Genotoxicity of phytoestrogens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005Plant extracts containing phytohormones are very popular as 'alternative' medicine for many kinds of diseases. They are especially favored by women who enter menopause and are concerned about the side effects of hormone replacement therapy. However, adverse health effects of phytoestrogens have often been ignored. This review examines the literature on
H, Stopper, E, Schmitt, K, Kobras
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Toxicology Mechanisms and Methods, 2014
Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Pınar, Erkekoglu, Belma, Kocer-Gumusel
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Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Pınar, Erkekoglu, Belma, Kocer-Gumusel
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Genotoxic and non-genotoxic pathways of p53 induction
Cancer Letters, 2001Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse forms of stress, including hypoxia and constitutive activation of growth-promoting cascades. The pathways by which these processes regulate p53 are partially overlapping, but imply different patterns of post-
O, Pluquet, P, Hainaut
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Hydroquinone: Genotoxicity and Prevention of Genotoxicity Following Ingestion
Food and Chemical Toxicology, 1999Plant-derived polyphenolics and other chemicals with antioxidant properties have been reported to inhibit the expression of genotoxic activity by pro-oxidant chemicals (Sai et al., 1992, 1994; Teel and Castonguay, 1992). In vitro and in vivo studies with ionizing radiation suggest that hydroquinone (HQ) may have similar protective effects (Babaev et al.
J, O'Donoghue +4 more
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