Results 311 to 320 of about 123,177 (344)
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Genotoxicity of Streptozotocin
Mutation Research/Reviews in Mutation Research, 2002Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
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2003
Bacterial mutagenesis assays have been used as preliminary screens for the evaluation of chemicals because they are rapid, simple, and are correlated with carcinogeneity in humans (1). The activation of bacterial DNA repair systems (recently reviewed; 2,3) can be used as a measure of mutagenic and genotoxic effects of various chemical as well as ...
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Bacterial mutagenesis assays have been used as preliminary screens for the evaluation of chemicals because they are rapid, simple, and are correlated with carcinogeneity in humans (1). The activation of bacterial DNA repair systems (recently reviewed; 2,3) can be used as a measure of mutagenic and genotoxic effects of various chemical as well as ...
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Mutation Research Letters, 1985
Unrelated, nondenatured, ethanol preparations, derived synthetically or by fermentation, were found to induce qualitatively similar concentration-dependent toxic and genotoxic effects as measured by RK mutatest. In this system ethanol was found genotoxic above a threshold concentration of 18-19% (v/v) when RK+ selector cells were transiently exposed ...
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Unrelated, nondenatured, ethanol preparations, derived synthetically or by fermentation, were found to induce qualitatively similar concentration-dependent toxic and genotoxic effects as measured by RK mutatest. In this system ethanol was found genotoxic above a threshold concentration of 18-19% (v/v) when RK+ selector cells were transiently exposed ...
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Genotoxic and non-genotoxic pathways of p53 induction
Cancer Letters, 2001Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse forms of stress, including hypoxia and constitutive activation of growth-promoting cascades. The pathways by which these processes regulate p53 are partially overlapping, but imply different patterns of post-
O, Pluquet, P, Hainaut
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Toxicology Mechanisms and Methods, 2014
Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Pınar, Erkekoglu, Belma, Kocer-Gumusel
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Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Pınar, Erkekoglu, Belma, Kocer-Gumusel
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Genotoxicity of phytoestrogens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005Plant extracts containing phytohormones are very popular as 'alternative' medicine for many kinds of diseases. They are especially favored by women who enter menopause and are concerned about the side effects of hormone replacement therapy. However, adverse health effects of phytoestrogens have often been ignored. This review examines the literature on
H, Stopper, E, Schmitt, K, Kobras
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Hydroquinone: Genotoxicity and Prevention of Genotoxicity Following Ingestion
Food and Chemical Toxicology, 1999Plant-derived polyphenolics and other chemicals with antioxidant properties have been reported to inhibit the expression of genotoxic activity by pro-oxidant chemicals (Sai et al., 1992, 1994; Teel and Castonguay, 1992). In vitro and in vivo studies with ionizing radiation suggest that hydroquinone (HQ) may have similar protective effects (Babaev et al.
J, O'Donoghue +4 more
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Genotoxicity testing strategies
Toxicology in Vitro, 1994Genotoxicity tests contribute to the assessment of whether a chemical has the potential to cause somatic or germ-cell effects in animals (i.e. the potential to induce cancer or heritable mutation). Such genotoxicity testing is usually undertaken in a stepwise approach; first an assessment in vitro, to determine intrinsic genotoxic activity, and ...
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Molecular Aspects of Medicine, 2003
Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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Genotoxicity and anti-genotoxicity of some traditional medicinal herbs
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005Six herbal infusions used worldwide (Matricaria chamomilla, Tilia cordata, Mentha piperita, Mentha pulegium, Uncaria tomentosa and Valeriana officinalis) were assayed for anti-genotoxicity using the Somatic Mutation And Recombination Test (SMART) in Drosophila melanogaster.
Magdalena, Romero-Jiménez +4 more
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