Results 311 to 320 of about 115,534 (346)
Some of the next articles are maybe not open access.
Quantifying genotoxicity and non-genotoxicity
Mutation Research/Genetic Toxicology, 1988Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of ...
Fanny K. Ennever, Herbert S. Rosenkranz
openaire +3 more sources
Chemical Research in Toxicology, 2023
Higher stress and anxiety levels are often reported globally. While anecdotal evidence has attributed a myriad of health conditions to stress, the mechanisms are often overlooked. Understanding the role of stress hormones on DNA damage/oxidative stress has implications for disease.
Renée L. Flaherty, Melanie S. Flint
openaire +2 more sources
Higher stress and anxiety levels are often reported globally. While anecdotal evidence has attributed a myriad of health conditions to stress, the mechanisms are often overlooked. Understanding the role of stress hormones on DNA damage/oxidative stress has implications for disease.
Renée L. Flaherty, Melanie S. Flint
openaire +2 more sources
Current Drug Metabolism, 2018
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ke Xu +4 more
openaire +3 more sources
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ke Xu +4 more
openaire +3 more sources
Genotoxicity of Streptozotocin
Mutation Research/Reviews in Mutation Research, 2002Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D. Bolzán, Martha S. Bianchi
openaire +3 more sources
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1993
Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
T. Bonin, C. Winder
openaire +3 more sources
Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
T. Bonin, C. Winder
openaire +3 more sources
2014
Genotoxicology is a major branch of ecotoxicology that deals with the genetic effects of environmental contaminants. Indeed, DNA is a target macromolecule for many pollutants that could lead to genetic mutations, loss of survival, altered cells, sometimes cell functions and proliferation leading to cancers.
Gagne, Francois +3 more
openaire +3 more sources
Genotoxicology is a major branch of ecotoxicology that deals with the genetic effects of environmental contaminants. Indeed, DNA is a target macromolecule for many pollutants that could lead to genetic mutations, loss of survival, altered cells, sometimes cell functions and proliferation leading to cancers.
Gagne, Francois +3 more
openaire +3 more sources
Toxicology Mechanisms and Methods, 2014
Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Belma Kocer-Gumusel, Pinar Erkekoglu
openaire +3 more sources
Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Belma Kocer-Gumusel, Pinar Erkekoglu
openaire +3 more sources
Genotoxicity of phytoestrogens
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2005Plant extracts containing phytohormones are very popular as 'alternative' medicine for many kinds of diseases. They are especially favored by women who enter menopause and are concerned about the side effects of hormone replacement therapy. However, adverse health effects of phytoestrogens have often been ignored. This review examines the literature on
Helga Stopper, K. Kobras, E. Schmitt
openaire +3 more sources
Genotoxic and non-genotoxic pathways of p53 induction
Cancer Letters, 2001Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse forms of stress, including hypoxia and constitutive activation of growth-promoting cascades. The pathways by which these processes regulate p53 are partially overlapping, but imply different patterns of post-
Pierre Hainaut, Olivier Pluquet
openaire +3 more sources
Hydroquinone: Genotoxicity and Prevention of Genotoxicity Following Ingestion
Food and Chemical Toxicology, 1999Plant-derived polyphenolics and other chemicals with antioxidant properties have been reported to inhibit the expression of genotoxic activity by pro-oxidant chemicals (Sai et al., 1992, 1994; Teel and Castonguay, 1992). In vitro and in vivo studies with ionizing radiation suggest that hydroquinone (HQ) may have similar protective effects (Babaev et al.
J Aebi +4 more
openaire +2 more sources