Results 1 to 10 of about 2,122,422 (355)
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis [PDF]
BMC Medicine, 2019 Background Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion.
WWARN K13 Genotype-Phenotype Study Group
doaj +3 more sources
Anderson Localization, Non-linearity and Stable Genetic Diversity [PDF]
, 2006 In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and mutation. Mutation operates as a generalized diffusion process on genotype space.
Charles L. Epstein +19 more
arxiv +3 more sources
The AGTR2 (RS11091046) Gene Polymorphism is Associated with Cycling Performance in Korean Cyclists [PDF]
운동과학, 2022 Purpose This study aimed to investigate the association between AGTR2 (rs11091046 A>C) gene polymorphism and athletic performance. Methods The Korean national team cyclists enrolled in the study performed 30-second Wingate test (peak power, mean power ...
Seok-ki Min +5 more
doaj +1 more source
The Hepatitis B Virus Genotypes E to J: The Overlooked Genotypes
Microorganisms, 2023 Hepatitis B virus (HBV) genotypes E to J are understudied genotypes. Genotype E is found almost exclusively in West Africa. Genotypes F and H are found in America and are rare in other parts of the world.
Rayana Maryse Toyé +5 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Objectives: To study the genetic and clinical characteristics of Chinese children with pathogenic proline-rich transmembrane protein 2 (PRRT2) gene-associated disorders.Methods: Targeted next generation sequencing (NGS) was used to identify pathogenic ...
Han-yu Luo +23 more
doaj +1 more source
Clinical pharmacology and therapy, 2022 CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition ...
Craig R. Lee +16 more
semanticscholar +1 more source
Donor IFNL4 Genotype Is Associated with Early Post-Transplant Fibrosis in Recipients with Hepatitis C [PDF]
, 2016 Background and Aims Early post-transplant hepatic fibrosis is associated with poor outcomes and may be influenced by donor/recipient genetic factors.
Aiken, Taylor +10 more
core +12 more sources
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022 Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima +9 more
wiley +1 more source