Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Retinal Dystrophies Associated with Mutations in the RP1 Gene: Genotype–Phenotype Correlations
Current Issues in Molecular BiologyBackground: We evaluated the genetic and phenotypic features of a cohort of 10 Italian patients affected by Retinitis Pigmentosa (RP) associated with RP1 sequence variants.
Vito Spagnuolo +11 more
doaj +1 more source
Effect of fertilizing on the productivity of pregnant and lactating queens, growth and development of their offspring [PDF]
Brazilian Journal of BiologyAn urgent problem in the agricultural science of livestock production is the adequate feeding of the queens of farm animals, in particular sheep kept on year-round pasture, especially in the second half of pregnancy and the first half of lactation. These
T. E. Kenzhebaev +5 more
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
THE POST-NONCLASSICAL STAGE OF CONCEPTUALIZATION OF THE TERM «HEREDITY»
Научный вестник МГТУ ГА, 2016 The peculiarities of conceptualization of the inheritance notion in the context of philosophical categories "property-substance", "internal-external" and other categories characteristic of the current period of post-non-classical stage of development of ...
A. A. Kochergin
doaj
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Hepatitis E virus infection among blood donors in Zhengzhou
Zhongguo shuxue zazhi[Objective] To analyze the infection status of hepatitis E virus (HEV) among blood donors in Zhengzhou, so as to provide data support for formulating local blood screening strategies.
ZHAO Hongna +8 more
doaj +1 more source
Genotype-environment interaction of genotypes of cocoa in Mexico
Scientific ReportsAbstract Cacao (Theobroma cacao L.) production is significantly influenced by genotype-environment interactions, which affect key agronomic traits such as yield, fruit quality, and disease resistance. Despite advances in cacao breeding, one of the main challenges remains the identification of stable, high-performing clones that can adapt to ...
Carlos Hugo Avendaño-Arrazate +5 more
openaire +3 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou
Zhongguo shuxue zazhi[Objective] To investigate the molecular prevalence and genotype of human parvovirus B19(B19) among blood donors in Lanzhou, and provide data support for monitoring the positive rate of B19 DNA in local blood donors.
WU Kangle +4 more
doaj +1 more source