Results 91 to 100 of about 1,140,258 (259)
, 2019 Although typical Newcastle disease virus (NDV) vaccines can prevent mortality, they are not effective in preventing viral shedding. To overcome this, genotype-matched vaccines have been proposed.
Ray Izquierdo-Lara (4614328) +9 more
core +1 more source
Clinical utility of panel-based genetic sequencing for von Willebrand disease
Research and Practice in Thrombosis and HaemostasisBackground: von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder with a wide spectrum of causative variants. Next-generation sequencing analyzes the entire VWF gene and provides concomitant assessment of other genes, allowing ...
Radha Ramanan +12 more
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Leber congenital amaurosis: A clinical and genetic study from a tertiary eye care center
Indian Journal of OphthalmologyPurpose: To assess the clinical phenotypes and genetic mutations in patients with Leber congenital amaurosis (LCA) from a tertiary eye care center in India. Design: Retrospective observational study.
Abhishek Upadhyaya +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Retinal Dystrophies Associated with Mutations in the RP1 Gene: Genotype–Phenotype Correlations
Current Issues in Molecular BiologyBackground: We evaluated the genetic and phenotypic features of a cohort of 10 Italian patients affected by Retinitis Pigmentosa (RP) associated with RP1 sequence variants.
Vito Spagnuolo +11 more
doaj +1 more source
Effect of fertilizing on the productivity of pregnant and lactating queens, growth and development of their offspring [PDF]
Brazilian Journal of BiologyAn urgent problem in the agricultural science of livestock production is the adequate feeding of the queens of farm animals, in particular sheep kept on year-round pasture, especially in the second half of pregnancy and the first half of lactation. These
T. E. Kenzhebaev +5 more
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
THE POST-NONCLASSICAL STAGE OF CONCEPTUALIZATION OF THE TERM «HEREDITY»
Научный вестник МГТУ ГА, 2016 The peculiarities of conceptualization of the inheritance notion in the context of philosophical categories "property-substance", "internal-external" and other categories characteristic of the current period of post-non-classical stage of development of ...
A. A. Kochergin
doaj