Results 71 to 80 of about 1,504,024 (293)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Molecular imaging is non-inferior to adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient study

Efficacy and Mechanism Evaluation
Background Primary aldosteronism due to a unilateral aldosterone-producing adenoma is a common cause of hypertension. This can be cured or greatly improved by adrenal surgery.
Xilin Wu, Alasdair McIntosh, Alex McConnachie, Mark Gurnell, William M Drake, Morris J Brown   +5 more
doaj   +1 more source

Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study

Frontiers in Oncology
BackgroundRenal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in VHL, chromatin remodeling genes such as SETD2 and genes that regulate the PI3K/AKT/mTOR pathway have been
Jakob Wieke, Christina Jurcic, Adam Kaczorowski, Sarah Böning, Martina Kirchner, Constantin Schwab, Viktoria Schütz, Markus Hohenfellner, Anette Duensing, Albrecht Stenzinger, Stefan Duensing   +10 more
doaj   +1 more source

Peculiarities of Tlr-2 (Arg753gln) and Tlr-4 (Asp299gly) Polymorphism Prevalence in Patients with Acute Brucelleis and Cardiovascular System Diseases [PDF]

, 2019
Currently, there are single data on the relationship between TLR-2 polymorphisms (Arg753Gln) and TLR-4 (Asp299Gly) polymorphisms and susceptibility to brucellosis.
Huseynov, E. M. (Elchin)
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genomic-based genotype and drug susceptibility profile of Mycobacterium kansasii in China

Frontiers in Microbiology
To analyze subtypes, microbiological characteristics and antimicrobial susceptibility of Mycobacterium kansasii in China, a total of 153 M. kansasii isolates, collected from national drug resistance surveillance, were genotyped with whole genome ...
Yiting Wang, Yiting Wang, Xichao Ou, Bing Zhao, Hui Xia, Yang Zheng, Yang Zhou, Ruida Xing, Yuanyuan Song, Shengfen Wang, Yanlin Zhao, Huiwen Zheng   +11 more
doaj   +1 more source

A variance components factor model for genetic association studies: a Bayesian analysis.

, 2010
Studies of gene-trait associations for complex diseases often involve multiple traits that may vary by genotype groups or patterns. Such traits are usually manifestations of lower-dimensional latent factors or disease syndromes.
Nonyane, BAS, Whittaker, JC
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Biological and morphological peculiarities of Lophanthus Adanson plants in the introduction in Kremenets botanical garden

Інтродукція Рослин, 2019
Objective – to conduct a comprehensive study of the biological and morphological characteristics of plants of the genus Lophanthus Adanson depending on the feeding area under the conditions of the Kremenets Botanical Garden. Material and methods.
O.A. Melnychuk
doaj   +1 more source

Neutral Aggregation in Finite Length Genotype space

, 2016
The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness.
Houchmandzadeh, Bahram
core   +3 more sources