Results 71 to 80 of about 1,113,934 (309)
, 2019 A) Workflow depicting erythroid colony (BFU-E) formation genotype/phenotype assay using edited HSPC. HSPC were edited using RNPs targeting the desired region, plated in methocult, and colonies were grown for 14 days.
Yukio Nakamura (39120) +11 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Scrapie-resistant sheep show certain coat colour characteristics [PDF]
, 2009 Susceptibility to scrapie is known to be associated with polymorphisms at the prion protein (PrP) gene, and this association is the basis of current selective programmes implemented to control scrapie in many Countries.
White, I +11 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Genotype-phenotype association by RDA
, 2019 This file provides all the all R codes (scripts) as well as the description of provided raw data to run the genotype-phenotype association analysis realized using a redundancy analysis (RDA) in this article.
Wilson, Christopher +9 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
, 2020 This study determined genotype-by-environment effect on grain quality among heat and drought tolerant bread wheat genotypes to select ideal genotypes for grain quality improvement.
Alfred Odindo (8711790) +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
SNP Genotyping and ApoE Genotyping v1
, 2021 This protocol details the steps for DNA extraction from a human blood sample, quality control, and SNP and APOE genotyping. The protocol has been adapted from the PRoBaND SNP Genotyping and ApoE Genotyping Protocol. The overall protocol for PRoBaND /Tracking Parkinson’s is published: Malek, N., Swallow, D. M. A., Grosset, K. A., Lawton, M.
Huw Morris +3 more
openaire +1 more source
Julius-Kühn-Archiv, 2016 Damask rose (Rosa damascena Mill.) is the most important species in the production of rose water, perfumes and essential oils (EOs), perfumery and pharmaceutical industry applications.
Karami, Akbar +2 more
doaj +1 more source