Results 61 to 70 of about 1,140,258 (259)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Genotype-phenotype correlations in patients from Russia with phenylketonuria (N = 1243).
, 2019 The genotype groups are marked with different shades of grey. Phenylketonuria was classified as stated in the Materials and Methods.
Polina Gundorova (5580134) +4 more
core +1 more source
Impact of Spontaneous Fermentation on the Physicochemical and Sensory Qualities of Cacao
FermentationFermentation is a fundamental technique that allows us to obtain high-quality cacao beans and derived products. Therefore, it is necessary to apply fermentation correctly to maximize product quality.
Lucas Fernando Quintana-Fuentes +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Smouse-et-al_JHered_mixed-assay-genotype-data_DATADRYAD
, 2013 Microsatellite genotypes and allele frequencies for datasets described in the paper. Included are genotypes for adult trees; pericarp- and leaf-derived genotypes for seedlings from open patches; and pericarp- and leaf-derived genotypes for seedlings from
Douglas G. Scofield (3311949) +3 more
core +1 more source
, 2023 The main objective of this study was to identify high-yielding and stable cotton genotypes under normal irrigation regimes and drought stress conditions using some biometrical methods including combined analysis of variance (ANOVA), joint regression ...
Essam Fathy El-Hashash (17583686) +4 more
core +1 more source
Veterinary SciencesPorcine epidemic diarrhea virus (PEDV), a primary pathogen causing diarrhea in pigs, particularly in piglets, has a mortality rate of up to 100%. Field PEDV strains circulating in pig production can be phylogenetically divided into two genotypes, GI and ...
Zhong Liu +10 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
, 2019 To evaluate whether genotype-guided antiplatelet therapy reduces the rates of cardiovascular events and bleeding events in patients with acute coronary syndrome (ACS).
Lukai Zheng (7351619) +3 more
core +1 more source
Guangxi Yike Daxue xuebaoThe unique reverse transcriptase of human immunodeficiency virus-1 (HIV-1) has no proofreading function, making it one of the fastest-mutating viruses and evolving into numerous subtypes and subclusters during the global epidemic. Different HIV-1 strains
LI Kang, SHAO Yiming
doaj +1 more source