Results 81 to 90 of about 1,504,024 (293)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Temporal variation of essential oils in dried flower of two genotypes of Damask rose (Rosa damascena Mill.)

Julius-Kühn-Archiv, 2016
Damask rose (Rosa damascena Mill.) is the most important species in the production of rose water, perfumes and essential oils (EOs), perfumery and pharmaceutical industry applications.
Karami, Akbar, Rousta, Pouya , Jowkar, Abolfazl   +2 more
doaj   +1 more source

Using genotype abundance to improve phylogenetic inference

, 2018
Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times.
DeWitt III, William S., Matsen IV, Frederick A., Mesin, Luka, Minin, Vladimir N., Victora, Gabriel D.   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Il-4 Polymorphism in Patients with Acute Brucellosis in the Republic of Azerbaijan [PDF]

, 2018
Currently, there are isolated data on the relationship between IL-4 polymorphism (C-589T) and susceptibility to brucellosis. Therefore, the purpose of the study was to determine the frequency of polymorphism of IL-4 (C-589T) in patients with acute ...
Huseynov, E. M. (Elchin)
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Phenotypic plasticity in trait performance of common dairy goat breeds under diverse environments: a systematic review

Frontiers in Animal Science
IntroductionDairy goat genotypes thrive across a range of ecological systems, making phenotypic plasticity highly relevant under constant environmental fluctuations. Maintaining production efficiency has become a priority for sustainable farming.
Puleng Kgabo Mashamaite, Obert Tada
doaj   +1 more source

How does SCYLV genetic diversity impact on Sugarcane disease resistance and breeding? [PDF]

, 2012
To date, six distinct genotypes of the Sugarcane yellow leaf virus have been described in the literature (BRA, CUB, CHN1, IND, PER and REU). However, little information is available regarding the impact of virus genetic diversity on disease resistance ...
Daugrois, Jean-Heinrich, Débibakas, Sarah   +1 more
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Evaluation of Epidemiological Manifestations of Tuberculosis and Genetic Diversity of Mycobacterium tuberculosis Strains with Multiple Drug Resistance in the Omsk Region

Эпидемиология и вакцинопрофилактика
Background. The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world.Aim: Evaluation of epidemiological manifestations of tuberculosis and molecular ...
I. V. Kostyukova, A. A. Vyazovaya, O. A. Pasechnik, I. V. Mokrousov   +3 more
doaj   +1 more source