Results 81 to 90 of about 1,140,258 (259)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Phenotypic plasticity in trait performance of common dairy goat breeds under diverse environments: a systematic review

Frontiers in Animal Science
IntroductionDairy goat genotypes thrive across a range of ecological systems, making phenotypic plasticity highly relevant under constant environmental fluctuations. Maintaining production efficiency has become a priority for sustainable farming.
Puleng Kgabo Mashamaite, Obert Tada
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Association of Metabolic Profiles with Hepatic Fibrosis in Chronic Hepatitis C Patients with Genotype 1 or 2 Infection

, 2011
Background and Aims: Metabolic profiles are associated with severity of liver histology in chronic hepatitis C (CHC) infection. However, the influence of hepatitis C virus (HCV) genotypes, especially genotype 1 and 2, on the association between metabolic
HSU, CHING-SHENG;LIU, CHEN-HUA;LIU, CHUN-JEN;HSU, SHIH-JER;CHEN, CHI-LING;HWANG, JUEY-JEN;LAI, MING-YANG;CHEN, PEI-JER;CHEN, DING-SHINN;KAO, JIA-HORNG, 許景盛;劉振驊;劉俊人;徐士哲;陳祈玲;黃瑞仁;賴明陽;陳培哲;陳定信;高嘉宏   +1 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Genotype-Year interaction ANOVA for fresh yield studied during three years.

Genotype-Year interaction ANOVA for fresh yield studied during three years.
Md. Ashraful Alam (7434188), Md. Atikur Rahman (13955704), Md. Riazul Islam (6270136), Ahmed Gaber (11917619), Srabanti Roy (14948968), Md. Mushfiqur Rahman (7382468), Md. Rafiqul Islam (403453), Akbar Hossain (12009419), Md. Marufur Rahman (14948962), Abu Jafor Obaidullah (17817288), Riyadh S. Almalki (17817294), Md. Nasirul Farid (17817291), Shailendra Nath Mozumder (14948971)   +12 more
core   +1 more source

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
Background Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant.
Montgomery, H, Harding, DR, Devadason David, Humphries, S, Whitelaw, A, David Davedason, Marlow Neil, Montgomery Hugh E, Marlow, N, Hugh E Montgomery, Davedason, D, Andrew Whitelaw, Humphries, SE, Neil Marlow, Montgomery, HE, Whitelaw Andrew, Humphries Steve E, Dhamrait Sukhbir, Devadason, D, Dhamrait, S, Steve E Humphries, Harding David R, David R Harding, Sukhbir Dhamrait   +23 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Genotype-Phenotype Relationship in Hereditary Haemochromatosis

, 2013
The majority of patients of northern European descent with Hereditary Hemochromatosis are homozygous for the C282Y mutation in the HFE gene product. A significant proportion of patients with this genotype have elevated iron indices, however most will not
Lachlan Ayres (23360197), John Olynyk (5735726), Vanoo Jayasekeran (23360200)   +2 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source