Results 81 to 90 of about 1,113,934 (309)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Smouse-et-al_JHered_mixed-assay-genotype-data_DATADRYAD
, 2013 Microsatellite genotypes and allele frequencies for datasets described in the paper. Included are genotypes for adult trees; pericarp- and leaf-derived genotypes for seedlings from open patches; and pericarp- and leaf-derived genotypes for seedlings from
Douglas G. Scofield (3311949) +3 more
core +1 more source
Genotype-by-temperature interactions for life span and its micro-environmental variance in the DGRP.
, 2020 Genotype-by-temperature interactions for life span and its micro-environmental variance in the DGRP.
W. Elizabeth Jones (5771492) +6 more
core +1 more source
, 2023 Data generated in the study 'Genotype-by-environment interaction for wheat falling number performance due to late maturity α-amylase'.
William Fairlie (4990463)
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Genotype-phenotype correlations in patients from Russia with phenylketonuria (N = 1243).
, 2019 The genotype groups are marked with different shades of grey. Phenylketonuria was classified as stated in the Materials and Methods.
Polina Gundorova (5580134) +4 more
core +1 more source
Frontiers in Animal ScienceIntroductionDairy goat genotypes thrive across a range of ecological systems, making phenotypic plasticity highly relevant under constant environmental fluctuations. Maintaining production efficiency has become a priority for sustainable farming.
Puleng Kgabo Mashamaite, Obert Tada
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source