Results 111 to 120 of about 2,216,855 (328)

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

Human Pappilomavirus Genotype in Cervical Tissue of Patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3 [PDF]

, 2016
Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo ...
Alia, R. (Rahmi), I’tishom, R. (Renny), Mastutik, G. (Gondo), Rahaju, A. S. (Anny), Rahniayu, A. (Alphania)   +4 more
core   +1 more source

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Nature Biotechnology, 2019
Daehwan Kim, Joseph M. Paggi, Chanhee Park, C. Bennett, S. Salzberg   +4 more
semanticscholar   +1 more source

Genetic Surfaceome E. coli Reprogramming Enables Selective Water Oxidation

Advanced Materials, EarlyView.
A novel enzymatic material based on bilirubin oxidase (BOD) surface‐expressed on E. coli for effective electrocatalysis is reported. With this material, highly efficient and selective water oxidation is achieved, a critical half reaction for synthetic photosynthesis. Abstract Programming catalytic behavior at the microbial genome level is a frontier in
Graziela C. Sedenho, Jéssica C. Pacheco, Melanie Gut, Filipe C. D. A. Lima, Sunanda Dey, Frank N. Crespilho, Ariel L. Furst   +6 more
wiley   +1 more source

Rate of photosynthetic induction in fluctuating light varies widely among genotypes of wheat. [PDF]

, 2019
Crop photosynthesis and yield are limited by slow photosynthetic induction in sunflecks. We quantified variation in induction kinetics across diverse genotypes of wheat for the first time.
Buckley, Thomas N, Merchant, Andrew M, Richards, Richard A, Salter, William T, Trethowan, Richard   +4 more
core  

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Science, 2015
K. Ardlie, David S. DeLuca, A. Segrè, Timothy J. Sullivan, Taylor Young, Ellen T. Gelfand, Casandra A. Trowbridge, Julian B. Maller, T. Tukiainen, M. Lek, Lucas D. Ward, Pouya Kheradpour, Benjamin Iriarte, Yan Meng, Cameron D. Palmer, T. Esko, W. Winckler, J. Hirschhorn, M. Kellis, D. MacArthur, Gad Getz, A. A. Shabalin, Gen Li, Yi-Hui Zhou, A. Nobel, I. Rusyn, Fred A. Wright, Tuuli Lappalainen, Pedro G. Ferreira, H. Ongen, Manuel A. Rivas, Alexis Battle, Sara Mostafavi, Jean Monlong, M. Sammeth, Marta Melé, F. Reverter, Jakob M. Goldmann, Daphne Koller, R. Guigó, Mark I. McCarthy, E. Dermitzakis, E. Gamazon, Hae K. Im, A. Konkashbaev, Dan L. Nicolae, Nancy J. Cox, T. Flutre, Xiaoquan Wen, Matthew Stephens, Jonathan K. Pritchard, Zhidong Tu, Bin Zhang, Tao Huang, Quan Long, Luan Lin, Jialiang Yang, Jun Zhu, Jun S. Liu, A. Brown, Bernadette Mestichelli, D. Tidwell, E. Lo, Mike Salvatore, Saboor Shad, Jeffrey A. Thomas, John T. Lonsdale, M. T. Moser, Bryan M. Gillard, E. Karasik, Kimberly Ramsey, Christopher Choi, Barbara A. Foster, John Syron, Johnelle Fleming, Harold Magazine, Rick Hasz, Gary Walters, J. Bridge, Mark Miklos, Susan Sullivan, Laura K. Barker, H. Traino, M. Mosavel, L. Siminoff, Dana R. Valley, D. Rohrer, Scott D. Jewell, P. Branton, L. Sobin, M. Barcus, L. Qi, J. McLean, P. Hariharan, K. S. Um, Shenpei Wu, David E. Tabor, C. Shive, Anna M. Smith, Stephen A. Buia, Anita H. Undale, Karna L. Robinson, Nancy V. Roche, Kimberly M. Valentino, Angela Britton, R. Burges, Debra Bradbury, Kenneth W. Hambright, John Seleski, G. Korzeniewski, Kenyon Erickson, Yvonne Marcus, Jorge Tejada, Mehran Taherian, Chunrong Lu, Margaret J. Basile, Deborah C. Mash, Simona Volpi, Jeffery P. Struewing, Gary F. Temple, Joy T. Boyer, Deborah Colantuoni, Roger Little, S. Koester, Latarsha J. Carithers, Helen M. Moore, P. Guan, Carolyn C. Compton, Sherilyn J. Sawyer, J. Demchok, Jimmie B. Vaught, C. Rabiner, Lockhart   +132 more
semanticscholar   +1 more source

Genotype and phenotype of COVID-19: Their roles in pathogenesis

Journal of Microbiology, Immunology and Infection, 2020
Leila Mousavizadeh, S. Ghasemi
semanticscholar   +1 more source

Response to: Clinical Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B

Annals of Clinical and Translational Neurology, EarlyView.
Sergi Borrego‐Écija, Cèlia Cruz‐Escalera, Agnes Perez‐Millán, Jordi Juncà‐Parellà   +3 more
wiley   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Collision‐Resilient Winged Drones Enabled by Tensegrity Structures

Advanced Robotics Research, EarlyView.
Based on structures of birds such as the woodpeck, this article presents the collision‐resilient aerial robot, SWIFT. SWIFT leverages tensegrity structures in the fuselage and wings which allow it to undergo large deformations in a crash, without sustaining damage. Experiments show that SWIFT can reduce impact forces by 70% over conventional structures.
Omar Aloui, Raphael Zufferey, William Stewart, Mohammad Askari, Simon Jeger, Dario Floreano   +5 more
wiley   +1 more source