Results 31 to 40 of about 904,642 (249)

Improving access to healthcare services for sickle cell disease patients in Nigeria: perspectives and views of healthcare professionals

Frontiers in Health Services
IntroductionIn sub-Saharan Africa, the burden of sickle cell disease remains high. With annual sickle cell births of about 150,000, Nigeria is reported to have the highest prevalence of the disease globally.
Godspower Onavbavba, Obi Peter Adigwe, Solomon Oloche Onoja   +2 more
doaj   +1 more source

Immunological and molecular epidemiological characteristics of acute and fulminant viral hepatitis A

Virology Journal, 2011
Background Hepatitis A virus is an infection of liver; it is hyperendemic in vast areas of the world including India. In most cases it causes an acute self limited illness but rarely fulminant.
Husain Syed A, Hussain Zahid, Almajhdi Fahad N, Kar Premashis   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Evolution of New Genotype of West Nile Virus in North America

Emerging Infectious Diseases, 2011
Previous studies of North American isolates of West Nile virus (WNV) during 1999–2005 suggested that the virus had reached genetic homeostasis in North America.
Allison R. McMullen, Fiona J. May, Li Li, Hilda Guzman, Rudy Bueno, James A. Dennett, Robert B. Tesh, Alan D.T. Barrett   +7 more
doaj   +1 more source

Global genetic diversity of measles virus (Paramyxoviridae: Morbillivirus: Morbillivirus hominis): historical aspects and current state

Вопросы вирусологии, 2023
Monitoring the circulation of the measles virus and studying its genetic diversity is an important component of the measles elimination program. A methodological approach to molecular genetic studies and their interpretation in the measles surveillance ...
Tatiana S. Rubalskaia, Denis V. Erokhov, Polina E. Zherdeva, Tamara A. Mamaeva, Nina T. Tikhonova   +4 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Genetic Risk of MASLD in Mongolians: Role of PNPLA3 and FTO SNPs

Current Issues in Molecular Biology
Background: This study aimed to determine the association between PNPLA3 rs738409, rs2896019, and FTO rs9939609, rs17817449 single-nucleotide polymorphisms and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in Mongolian ...
Yumchinsuren Tsedendorj, Dolgion Daramjav, Yesukhei Enkhbat, Ganchimeg Dondov, Gantogtokh Dashjamts, Enkhmend Khayankhyarvaa, Amin-Erdene Ganzorig, Bolor Ulziitsogt, Tegshjargal Badamjav, Batbold Batsaikhan, Shiirevnyamba Avirmed, Tulgaa Lonjid   +11 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

MOLECULAR CHARACTERIZATION OF ROTAVIRUSES ISOLATED FROM CALVES WITH BOVINE NEONATAL DIARRHEA (BND) IN COLOMBIA

Infectio, 2018
Bovine rotaviruses are one of the main agents involved in the presentation of Bovine Neonatal Diarrhea (BND), a disease that affects calves in the first month of life.
Dolly Pardo-Mora
doaj   +1 more source

The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain

Vaccines, 2021
This study evaluated the long-term impact of rotavirus vaccination on prevalence, seasonality, and genotype distribution in Gwangju, Korea for 13 seasons.
Kwang gon Kim, Hye-young Kee, Hye jung Park, Jae Keun Chung, Tae sun Kim, Min Ji Kim   +5 more
doaj   +1 more source