Results 31 to 40 of about 1,614,514 (332)

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group

Clinical and Translational Science, 2019
Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and ...
K. Caudle, K. Sangkuhl, Michelle Whirl‐Carrillo, J. Swen, Cyrine E. Haidar, T. Klein, Roseann S. Gammal, M. Relling, S. Scott, D. Hertz, H. Guchelaar, A. Gaedigk   +11 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

HPV Genotype Trends in Iran: Necessity for a Reevaluation of Prevention Strategies

Tropical Medicine and Infectious Disease
Introduction: Human papillomavirus (HPV) genotyping is critical for preventing and managing HPV-related health issues, including cancers. This study re-evaluates HPV genotype trends in Iran to inform prevention strategies.
Maryam Shahi, Azam Shafaei, Mohamad Ghodsi, Reza Jafarzadeh Esfehani, Mahdi Moradi Marjaneh   +4 more
doaj   +1 more source

Commercial layer hybrids kept under organic conditions: a comparison of range use, welfare, and egg production in two layer strains

Poultry Science, 2022
: Outdoor range areas provide laying hens with improved opportunities to perform natural behaviors and increase the available space per bird, however, birds are also exposed to potentially stressful factors including weather and predators.
K.E. Wurtz, K. Thodberg, A. Berenjian, L. Foldager, F.M. Tahamtani, A.B. Riber   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Epidemiological features of viral hepatitis C in the Tomsk region

Инфекция и иммунитет
Introduction. Despite the great advances made in the field of virology and their diagnostics, a number of difficulties affect improvements in the control and elimination of hepatitis C virus (HCV) infection at present.
Yu. A. Ermolaeva, I. R. Grishkevich, Yu. G. Samoilova   +2 more
doaj   +1 more source

Beijing Lineage of MDR Mycobacterium tuberculosis in Bulgaria, 2007–2011

Emerging Infectious Diseases, 2014
To assess the spread of the Mycobacterium tuberculosis Beijing genotype among patients with multidrug-resistant and extensively resistant tuberculosis in Bulgaria, we genotyped 188 (72%) of 261 microbiologically confirmed resistant isolates obtained ...
Stefan Panaiotov, Elizabeta Bachiyska, Stanislava Yordanova, Yuliana Atanasova, Nadia Brankova, Viktoria Levterova, Sarah Sengstake, Richard M. Anthony, Indra Bergval, Christophe Sola, Todor Kantardjiev   +10 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review

Journal of Fungi, 2021
The genus Cryptococcus contains two primary species complexes that are significant opportunistic human fungal pathogens: C. neoformans and C. gattii.
Marhiah C. Montoya, Paul M. Magwene, John R. Perfect   +2 more
doaj   +1 more source

PhenoScanner: a database of human genotype–phenotype associations

Bioinform., 2016
Summary: PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of genetic variants with many phenotypes, to help aid ...
James R. Staley, James A. Blackshaw, M. Kamat, Steve Ellis, P. Surendran, B. Sun, D. Paul, Daniel F. Freitag, S. Burgess, J. Danesh, R. Young, A. Butterworth   +11 more
semanticscholar   +1 more source