Results 51 to 60 of about 134,396 (261)

Genotype by Environment Interaction and Yield Stability of Drought Tolerant Mung Bean [Vigna radiata (L.) Wilczek] Genotypes in Ethiopia [PDF]

, 2022
A multi-environment evaluation of mung bean genotypes was conducted in six environments across Ethiopia to select promising genotypes. This study was conducted to estimate the magnitude of genotypes by environment interaction (GEI) and seed yield ...
Mekbib, Firew, Ganta, Tekle Yoseph, Tadele, Zerihun, Amsalu, Berhanu   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A multi-trait multi-environment QTL mixed model with an application to drought and nitrogen stress trials in maize (Zea mays L.)

, 2008
Despite QTL mapping being a routine procedure in plant breeding, approaches that fully exploit data from multi-trait multi-environment (MTME) trials are limited.
Crossa, J., Malosetti, M., Vargas, M., Ribaut, J.M., Eeuwijk, F.A., van   +4 more
core   +1 more source

Proportion of the variations in heartwood color traits explained by genotype, environment, and the interaction between genotype and environment (i.e., plasticity).

, 2022
Proportion of the variations in heartwood color traits explained by genotype, environment, and the interaction between genotype and environment (i.e., plasticity).
Yoshihiko Tsumura (408539), Takahiro Yoshida (461333), Ryota Endo (2713057), Tokuko Ujino-Ihara (487192), Asako Matsumoto (5440334), Kana Yamashita (8368014), Yoshimi Sakai (836800), Ryouichi Kusano (13007532), Hideki Mori (1709440), Seiichi Kanetani (4694275), Takeshi Fujiwara (170826), Kentaro Uchiyama (487189), Yoshinari Moriguchi (487191), Saneyoshi Ueno (408537)   +13 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genomic Prediction of Genotype × Environment Interaction Kernel Regression Models

The Plant Genome, 2016
In genomic selection (GS), genotype × environment interaction (G × E) can be modeled by a marker × environment interaction (M × E). The G × E may be modeled through a linear kernel or a nonlinear (Gaussian) kernel.
Jaime Cuevas, José Crossa, Víctor Soberanis, Sergio Pérez-Elizalde, Paulino Pérez-Rodríguez, Gustavo de los Campos, O. A. Montesinos-López, Juan Burgueño   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bayesian Genomic Prediction with Genotype × Environment Interaction Kernel Models

G3: Genes, Genomes, Genetics, 2017
The phenomenon of genotype × environment (G × E) interaction in plant breeding decreases selection accuracy, thereby negatively affecting genetic gains.
Jaime Cuevas, José Crossa, Osval A. Montesinos-López, Juan Burgueño, Paulino Pérez-Rodríguez, Gustavo de los Campos   +5 more
doaj   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2010
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
Amato, Roberto, G. Raiconi, ROBERTO AMATO, Miele, Gennaro, Nicodemi Mario, D. D'Andrea, Amato Roberto, AND SERGIO COCOZZA, MARIO NICODEMI, MICHELE PINELLI, Nicodemi, Mario, D'Andrea Daniel, Pinelli, Michele, Sergio Cocozza, Raiconi, Giancarlo, GENNARO MIELE, Amato, R. (Roberto), Cocozza Sergio, Raiconi Giancarlo, Miele Gennaro, Giancarlo Raiconi, D’Andrea, Daniel, Cocozza, Sergio, Pinelli Michele, DANIEL D'ANDREA   +24 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source