Results 111 to 120 of about 6,439,956 (330)

Diminishing Use of Liver Biopsy among Liver Transplant Recipients for Hepatitis C. [PDF]

, 2017
Background and Aims: Hepatitis C virus (HCV) cirrhosis is the leading indication for liver transplantation in the United States and recurrent HCV following liver transplantation is a major cause of allograft loss and mortality.
Aby, Elizabeth, Agopian, Vatche, Busuttil, Ronald W, French, Samuel W, Grotts, Jonathan F, Jimenez, Melissa A, Saab, Sammy   +6 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Association of ACE Genotypes on Cardiorespiratory Variables Related to Physical Fitness in Healthy Men. [PDF]

PLoS ONE, 2016
Aerobic power (VO2max), aerobic capacity (RCP), and running efficiency (RE) are important markers of aerobic fitness. However, the influence of the angiotensin converting enzyme (ACE) polymorphism on these markers has not been investigated in healthy ...
Salomão Bueno, Leonardo A Pasqua, Gustavo de Araújo, Adriano Eduardo Lima-Silva, Rômulo Bertuzzi   +4 more
doaj   +1 more source

Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction [PDF]

, 2014
Introduction: Disturbance of the uteroplacental circulation (UPC) and the renin-angiotensin system are involved in the pathogenesis of preeclampsia. In women with history of preeclampsia persistently elevated C-reactive protein (CRP) levels have been ...
Hoppe, Berthold, Häupl, Thomas, Kalus, Ulrich, Koscielny, Jürgen, Yürek, Salih, Zimmermann, Mathias   +5 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Development and application of a SYBR Green I fluorescent PCR assay for the differentiation of genotypes I and II African swine fever viruses

Animal Diseases
African swine fever (ASF) is a highly fatal hemorrhagic disease affecting domestic pigs caused by African swine fever virus (ASFV). Genetic analysis of ASFV isolates to date has identified 24 geographically related genotypes with various subgroups, but ...
Xuexiang Yu, Haowei Wu, Dongfan Li, Qian Xu, Xiaoyu Chen, Chengjun Zhang, Fengqin Xu, Xugang Ku, Qigai He, Wentao Li   +9 more
doaj   +1 more source

The Influence of ACE Insertion/Deletion Gene Polymorphism on the Risk of IgA Nephropathy: A Debatable Topic

Genetics Research, 2021
Background. The connection between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphisms and IgA nephropathy (IgAN) was conflicting. This pooled analysis was performed to explore this issue. Methods.
Fen-Fen Chu, Shi-Kun Yang, Wen-Li Zeng
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Gene Polymorphism of the Angiotensin I-Converting Enzyme Correlates with Tumor Size and Patient Survival in Colorectal Cancer Patients

Neoplasia: An International Journal for Oncology Research, 2007
We studied the putative significance of angiotensin I-converting enzyme (ACE) in colorectal cancer (CRC) biology. Local expression of ACE was investigated by quantitative reverse transcription- polymerase chain reaction and by immunohistochemistry in ...
Christoph Röcken, Konrad Neumann, Stacy Carl-McGrath, Hermann Lage, Matthias P.A. Ebert, Jutta Dierkes, Christoph A. Jacobi, Sinan Kalmuk, Peter Neuhaus, Ulf Neumann   +9 more
doaj   +1 more source

Towards the Evolution of Multi-Layered Neural Networks: A Dynamic Structured Grammatical Evolution Approach

, 2017
Current grammar-based NeuroEvolution approaches have several shortcomings. On the one hand, they do not allow the generation of Artificial Neural Networks (ANNs composed of more than one hidden-layer. On the other, there is no way to evolve networks with
Assuncao Filipe, Fedorovici Lucian-Ovidiu, Gomez Faustino, Ryan Conor, Si Tapas, Sigillito Vincent G., Street W. Nick, Tirumala Sreenivas Sremath   +7 more
core   +1 more source