Results 121 to 130 of about 10,430,018 (295)

Growth, nutrient acquisition and physiological responses of papaya (Carica papaya) plants to controlled low temperature stress

The Indian Journal of Agricultural Sciences, 2018
Study of physiological response of different papaya (Carica papaya L.) genotypes to low temperature stress is of paramount importance owing to its higher susceptibility.The present study was conducted under controlled conditions of National Phytotron ...
SATYABRATA PRADHAN, A K GOSWAMI, S K SINGH, JAI PRAKASH, SUNEHA GOSWAMI, CHINNUSAMY VISWANATHAN, AKSHAY TALUKDAR, V K SHARMA   +7 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Role of ledipasvir/sofosbuvir combination for genotype 1 hepatitis C virus infection

, 2016
Vinay Sundaram,1 Kris V Kowdley21Department of Medicine and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 2Liver Care Network, Swedish Medical Center, Seattle, WA, USAAbstract: Chronic hepatitis C virus (HCV) infection is
Kowdley KV, Sundaram V
core  

Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, São Paulo State

Viruses
Dengue virus (DENV) is a prominent arbovirus with global spread, causing approximately 390 million infections each year. In Brazil, yearly epidemics follow a well-documented pattern of serotype replacement every three to four years on average. Araraquara,
Caio Santos de Souza, Giovana Santos Caleiro, Ingra Morales Claro, Jaqueline Goes de Jesus, Thaís Moura Coletti, Camila Alves Maia da Silva, Ângela Aparecida Costa, Marta Inenami, Andreia C. Ribeiro, Alvina Clara Felix, Anderson Vicente de Paula, Walter M. Figueiredo, Expedito José de Albuquerque Luna, Ester C. Sabino, Camila M. Romano   +14 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Genotype-Phenotype Relationship in Hereditary Haemochromatosis

, 2013
The majority of patients of northern European descent with Hereditary Hemochromatosis are homozygous for the C282Y mutation in the HFE gene product. A significant proportion of patients with this genotype have elevated iron indices, however most will not
Lachlan Ayres (23360197), John Olynyk (5735726), Vanoo Jayasekeran (23360200)   +2 more
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Characterization of genotype V Japanese encephalitis virus isolates from Republic of Korea

Emerging Microbes & Infections
Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV) infection, continues to pose significant public health challenges worldwide despite efficient vaccines. The virus is classified into five genotypes, among which genotype V (GV) was not detected for a long period after its initial isolation in 1952, until reports emerged from ...
Ah-Ra Lee, Sang-Hyun Kim, Su-Yeon Hong, Sang-Ho Lee, Jae Sang Oh, Kyung Yong Lee, Seong-Jun Kim, Tomohiro Ishikawa, Sang-Mu Shim, Hee Il Lee, Sang-Uk Seo   +10 more
openaire   +3 more sources