Results 61 to 70 of about 10,430,018 (295)

Association of GH gene polymorphism with growth and semen traits in rabbits

World Rabbit Science, 2021
Although growth hormone (GH) gene mutations are described in several species, the studies concerning their variabilities and associations with economic traits in rabbits are scarce, particularly associations with semen traits. A total of 149 rabbit bucks
Maher Hasab El-Nabi Khalil, Abdelfatah R. Zaghloul, Mahmoud M. Iraqi, Ayman G. El Nagar, Sherif I. Ramadan   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Multicenter Evaluation of PCR Methods for the Detection of Factor V Leiden (R506Q) Genotypes [PDF]

Clinical Chemistry, 1998
Activated protein C (APC) resistance is reported to be present in 20–60% of individuals with a history of venous thrombosis (1). Thus, the prevalence of APC resistance in Caucasian patients with a history of venous thromboembolism is much greater than the prevalence of protein C deficiency, protein S deficiency, or antithrombin deficiency (1).
C T, Lutz, P A, Foster, W W, Noll, K V, Voelkerding, R D, Press, R C, McGlennen, N E, Kirschbaum   +6 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ablation and antiarrhythmic drug effects on PITX2+/− deficient atrial fibrillation: A computational modeling study

Frontiers in Cardiovascular Medicine, 2022
IntroductionAtrial fibrillation (AF) is a heritable disease, and the paired-like homeodomain transcription factor 2 (PITX2) gene is highly associated with AF.
Ze Jin, Inseok Hwang, Byounghyun Lim, Oh-Seok Kwon, Je-Wook Park, Hee-Tae Yu, Tae-Hoon Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak   +9 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Evolutionary history and spatiotemporal dynamics of DENV-1 genotype V in the Americas

Infection, Genetics and Evolution, 2016
The genotype V has been the most prevalent dengue virus type 1 (DENV-1) clade circulating in the Americas over the last 40years. In this study, we investigate the spatiotemporal pattern of emergence and dissemination of DENV-1 lineages in the continent.
Fernanda, de Bruycker-Nogueira, Daiana, Mir, Flavia Barreto, Dos Santos, Gonzalo, Bello   +3 more
openaire   +2 more sources

Vitamin-V: Virtual Environment and Tool-boxing for Trustworthy Development of RISC-V based Cloud Services [PDF]

, 2023
Vitamin-V is a 2023-2025 Horizon Europe project that aims to develop a complete RISC-V open-source software stack for cloud services with comparable performance to the cloud-dominant x86 counterpart and a powerful virtual execution environment for ...
I. Papaefstathiou, A. Arelakis, J. L. Berral, Y. Nikolakopoulos, A. Call, V. Karakostas, A. Torregrosa, K. Nikas, J. Costa, E. Rodríguez, R. Canal, A. Rigo, F. Lubrano, A. Scionti, D. Gizopoulos, D. Pnevmatikatos, G. Papadimitriou, J. M. Arnau, A. Savino, N. Tampouratzis, S. Di Carlo, D. Raho, B. Otero   +22 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Scrapie-resistant sheep show certain coat colour characteristics [PDF]

, 2009
Susceptibility to scrapie is known to be associated with polymorphisms at the prion protein (PrP) gene, and this association is the basis of current selective programmes implemented to control scrapie in many Countries.
White, I, Brotherstone, S., White, I., Sawalha, RM, Villanueva, B., Villanueva, B, Wilson, A. J., Brotherstone, S, Wilson, AJ, Bell, L., Bell, L, Sawalha, R. M.   +11 more
core   +1 more source