Results 71 to 80 of about 10,430,018 (295)

Characterization of a Novel Cotton Subtilase Gene GbSBT1 in Response to Extracellular Stimulations and Its Role in Verticillium Resistance. [PDF]

PLoS ONE, 2016
Verticillium wilt is a disastrous vascular disease in plants caused by Verticillium dahliae. Verticillium pathogens secrete various disease-causing effectors in cotton.
Xingpeng Duan, Zhidong Zhang, Jin Wang, Kaijing Zuo   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Fc‐gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer

Cancer Medicine, 2018
Background Two germ line Fc‐γ receptor (FCGR) polymorphisms, rs1801274 [FCGR2A; His(H)131Arg(R)] and rs396991 [FCGR3A; Phe(F)158Val(V)], produce altered proteins through amino acid substitutions.
Daniel Shepshelovich, Amanda R. Townsend, Osvaldo Espin‐Garcia, Lidija Latifovic, Chris J. O’Callaghan, Derek J. Jonker, Dongsheng Tu, Eric Chen, Eric Morgen, Timothy J. Price, Jeremy Shapiro, Lillian L. Siu, Michiaki Kubo, Alexander Dobrovic, Mark J. Ratain, Wei Xu, Taisei Mushiroda, Geoffrey Liu   +17 more
doaj   +1 more source

First evidence of the presence of genotype-1 of Japanese encephalitis virus in Culex gelidus in Indonesia

Parasites & Vectors, 2019
Background Japanese encephalitis has become a public health threat in Indonesia. Three genotypes have been recorded in Indonesia, i.e. genotype II (GII), genotype III (GIII) and genotype IV (GIV).
Triwibowo Ambar Garjito, Mega Tyas Prihatin, Lulus Susanti, Dhian Prastowo, Siti Rofiatus Sa’adah, Yulian Taviv, Tri Baskoro Tunggul Satoto, Joko Waluyo, Sylvie Manguin, Roger Frutos   +9 more
doaj   +1 more source

Amino Acid at Position 166 of NS2A in Japanese Encephalitis Virus (JEV) Is Associated with In Vitro Growth Characteristics of JEV

Viruses, 2020
We previously showed that the growth ability of the Japanese encephalitis virus (JEV) genotype V (GV) strain Muar is clearly lower than that of the genotype I (GI) JEV strain Mie/41/2002 in murine neuroblastoma cells.
Shigeru Tajima, Satoshi Taniguchi, Eri Nakayama, Takahiro Maeki, Takuya Inagaki, Chang-Kweng Lim, Masayuki Saijo   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Association between Glutathione S-Transferase GSTM1-T1 and P1 Polymorphisms with Metabolic Syndrome in Zoroastrians in Yazd, Iran

Iranian Journal of Public Health, 2015
Background: The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S-transferase (GST) gene family and the risk of the development of metabolic syndrome (MS) in Zoroastrian females in Yazd, Iran ...
Mohammadhosain Afrand, Nasrollah Bashardoost, Mohammad Hasan Sheikhha, Mohammad Afkhami-Ardekani   +3 more
doaj  

First detection and molecular characterization of a DENV‐1/DENV‐4 co‐infection during an epidemic in Rio de Janeiro, Brazil

Clinical Case Reports, 2018
Key Clinical Message In the 80s, dengue viruses type 1 and 4 (DENV‐1 and 4) were isolated in North region of Brazil. However, it was only after the DENV‐1 introduction in the state of Rio de Janeiro (RJ) in mid‐1980s, that dengue became a nationwide ...
Fernanda de Bruycker‐Nogueira, Nieli Rodrigues da Costa Faria, Priscila Conrado Guerra Nunes, Rita Maria Ribeiro Nogueira, Ana Maria Bispo de Filippis, Flavia Barreto dos Santos   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genotype-Specific Vector Competence of Aedes albopictus for Japanese Encephalitis Virus Genotypes I, III, and V

Viruses
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, poses a significant public health threat in Asia. Although Culex species are primary vectors, the role of Aedes albopictus in JEV transmission has gained attention under changing ecological conditions. This study evaluated the vector competence of Ae. albopictus for three JEV genotypes: I (
Bo-Ram Yun, Ji-Young Kwon, Dongmi Kwak, Hee Il Lee   +3 more
openaire   +3 more sources