Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Multi-environment evaluation and genomic prediction of agronomic traits in the southern US rice genepool. [PDF]
Plant GenomeLaPorte MF +8 more
europepmc +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Genotypic modulation of nanoparticles-induced tolerance in heavy metals-stressed crops; a literature review. [PDF]
Front Plant SciHammad M +4 more
europepmc +1 more source
Study of a Novel Bi‐Layered Thermoplastic Polyurethane Patch for Congenital Diaphragmatic Hernia
Advanced Materials Interfaces, EarlyView.Large congenital diaphragmatic hernia remains a challenge due to the poor compatibility of current prostheses. To tackle this problem, a bilayer thermoplastic polyurethane patch with tunable mechanical properties is engineered, whose fibrous side supports rapid fibroblast and myoblast colonization, while the smooth film limits adhesions.
Guillaume Leks +14 more
wiley +1 more source
The Brief Case: Adjudication of discrepant genotypic and phenotypic antimicrobial susceptibility testing results in a patient with <i>Staphylococcus aureus</i> bacteremia. [PDF]
J Clin MicrobiolReyes Curcio F +5 more
europepmc +1 more source
Collision‐Resilient Winged Drones Enabled by Tensegrity Structures
Advanced Robotics Research, EarlyView.Based on structures of birds such as the woodpeck, this article presents the collision‐resilient aerial robot, SWIFT. SWIFT leverages tensegrity structures in the fuselage and wings which allow it to undergo large deformations in a crash, without sustaining damage. Experiments show that SWIFT can reduce impact forces by 70% over conventional structures.
Omar Aloui +5 more
wiley +1 more source
Allele and genotype frequencies of the SOD1 c.118G>A mutation associated with degenerative myelopathy in Boxer and Pit Bull Terrier dogs from Uruguay. [PDF]
Braz J Vet MedArtigas R +6 more
europepmc +1 more source
Advanced Science, EarlyView.Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee +9 more
wiley +1 more source