Results 41 to 50 of about 214,572 (265)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Phenotypic and molecular analysis of Pseudomonas aeruginosa virulence and association with antibiotic resistance in Egypt

Journal of Infection in Developing Countries
Introduction: Pseudomonas aeruginosa is a common nosocomial pathogen with multidrug resistance (MDR) and virulence factors (VFs). This study assessed the VFs and their associations with MDR and non-MDR isolates.
Salah AI Ali, Aya A Ghamry, Amal M Soliman, Abdullah M Abdo, Nagwan G El-Menofy, Manal M Al-Gerby, Haytham K Mahrous   +6 more
doaj   +1 more source

Pyrazinamide phenotypic and genotypic drugs susceptibility results.

, 2022
Pyrazinamide phenotypic and genotypic drugs susceptibility results.
Nomonde Ritta Mvelase (13840309), Ravesh Singh (358400), Koleka Patience Mlisana (13840312), Khine Swe Swe-Han (6596060)   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The genotypic table.

, 2014
The genotypic table.
Ruijie Zhang (194261), Mingming Zhang (362844), Guiyou Liu (224712), Hongchao Lv (295175), Yongshuai Jiang (194259), Fanwu Kong (525750), Rennan Feng (186785), Lanying Zhang (295177), Jin Li (119007), Mingzhi Liao (473967)   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

High proportion of tuberculosis recent transmission in rural areas of Northeastern China: a 3-year prospective population-based genotypic and spatial analysis in Hinggan League, China

Microbiology Spectrum
Tuberculosis (TB) remains a significant public health challenge in China, particularly in rural areas like Hinggan League (HL), Inner Mongolia. Understanding the genetic diversity and transmission dynamics of Mycobacterium tuberculosis (MTB) strains is ...
Xichao Ou, Xiangchen Li, Shaojun Pei, Bing Zhao, Liping Feng, Chong Teng, Yewei Lu, Hanfang Zhu, Yang Zhou, Hui Xia, Zhengwei Liu, Xiaomeng Wang, Yanling Wang, Richard Anthony, Yanlin Zhao   +14 more
doaj   +1 more source

PHENOTYPIC AND GENOTYPIC DETECTION OF METHICILLIN- RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN BROILER CHICKENS [PDF]

Assiut Veterinary Medical Journal, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) has been increasingly reported as emerging problem in veterinary medicine, particularly in small animals and poultry. In Egypt, there is limited information on MRSA carriage in poultry.
AML A.M. BAKEET, SAMAH F. DARWISH
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Prevalence of colonization and mitochondrial large subunit rRNA mutation of Pneumocystis jiroveci among Iranian children

Iranian Journal of Microbiology, 2016
Background and Objectives: Pneumocystis jiroveci is an important causative agent of Pneumocystis pneumonia. During childhood, exposure to Pneumocystis occurs and antibody was built in early childhood.
Parisa Badiee, Ali Rezapour, Amin Abbasian, Hamid Reza Foroutan, Hadis Jafarian   +4 more
doaj