Results 51 to 60 of about 214,572 (265)

Genotypic fidelity of LCL.

, 2013
Genotypic fidelity is shown as mean pairwise distances among 19 paired comparisons of LCL and PBMC genotypes, for increasingly stringent SNP filtering by population call rate. A) Genotypic fidelity between LCL and PBMC source DNA from the same individual,
Joseph B. Margolick (255437), James I. Mullins (30582), Geoffrey S. Gottlieb (235246), Lisa P. Jacobson (255443), Charles R. Rinaldo (235434), Joshua T. Herbeck (214670), Roger Detels (255434), John P. Phair (370682), Kim Wong (262770)   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

bur_plate_loc - Genotypic microsatellite data in GENEPOP format

, 2015
Genotypic microsatellite data (GENEPOP) format used in Ravinet et al (2015) MS. File contain genotypic data for 14 microsatellite data four for population samples.
Phil McGinnity (410880), Cross, Tom F., Harrod, Harrod, Ravinet, Mark, Russell Poole (723439), Mark Ravinet (3259092), Prodöhl, Paulo A., Paulo A. Prodöhl (723440), McGinnity, Phil, Tom F. Cross (410884), Poole, Russell, Rosaleen Hynes (723438), Harrod Harrod (3276807), Hynes, Rosaleen   +13 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Parallel Detection of the Unamplified Carbapenem Resistance Genes bla_NDM-1 and bla_OXA-1 Using a Plasmonic Nano-Biosensor with a Field-Portable DNA Extraction Method

Biosensors
Antimicrobial resistance (AMR) is a rapidly growing global concern resulting from the overuse of antibiotics in agricultural and clinical settings.
Kaily Kao, Evangelyn C. Alocilja
doaj   +1 more source

EVALUATION OF DIFFERENT BREAD WHEAT LINES IN THE F6 AND F7 GENERATION FOR GRAIN YIELD AND ITS ATTRIBUTES [PDF]

Journal of Plant Production, 2000
This investigation was carried out to evaluate 66 wheat lines derived from five crosses of bread wheat along with their seven parents and ten check cultivars giving a total of 83 genotypes. The 66 lines were evaluated in the F6 and F7 generations in 1995/
Afaf Tolba,
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Novel mutation detection of fibroblast growth factor receptor 1 (FGFR1) gene, FGFR2IIIa, FGFR2IIIb, FGFR2IIIc, FGFR3, FGFR4 gene for craniosynostosis: A prospective study in Asian Indian patient

Journal of Pediatric Neurosciences, 2015
Background: Craniosynostosis (CS) syndrome is an autosomal dominant condition classically combining craniosynostosis and non-syndromic craniosynostosis with digital anomalies of the hands and feet.
Mayadhar Barik, Minu Bajpai, Arun Malhotra, Jyotish Chandra Samantaray, Sadananda Dwivedi, Sambhunath Das   +5 more
doaj   +1 more source

Phenotypic and Genotypic Trends for Some Economic Traits in Egyptian Buffaloes [PDF]

Journal of Animal and Poultry Production, 2017
A total of 2763 lactation records of Egyptian buffaloes, sired by 147 bulls, were collected from Mahalla Mousa Farm, Kafer El sheihk Government. Traits studied are milk production (MP), lactation length (LL) and age of heifers at calving (AHC).
Set El- Habiab Awad, Amina Ahmad, A. Khattab, Shymaa El – Komy   +3 more
doaj   +1 more source

Genotypic characterization of 3S region.

, 2012
Genotypic characterization of 3S region.
Bonaventura Clotet (91238), Cecilia Cabrera (186331), María Pernas (186326), Vincent Vieillard (186338), Marta Massanella (91231), Patrice Debré (186335), Julià Blanco (91239), Marta Curriu (91234), Jorge Carrillo (186329), Hughes Fausther-Bovendo (186322), Cecilio López-Galíndez (186333)   +10 more
core   +1 more source