Results 51 to 60 of about 189,911 (267)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Parallel Detection of the Unamplified Carbapenem Resistance Genes bla_NDM-1 and bla_OXA-1 Using a Plasmonic Nano-Biosensor with a Field-Portable DNA Extraction Method

Biosensors
Antimicrobial resistance (AMR) is a rapidly growing global concern resulting from the overuse of antibiotics in agricultural and clinical settings.
Kaily Kao, Evangelyn C. Alocilja
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Early phase of effective treatment induces distinct transcriptional changes in Mycobacterium tuberculosis expelled by pulmonary tuberculosis patients

Scientific Reports, 2021
Effective treatment reduces a tuberculosis patient's ability to infect others even before they test negative in sputum or culture. Currently, the basis of reduced infectiousness of the Mycobacterium tuberculosis (Mtb) with effective treatment is unclear.
Ambreen Shaikh, Kalpana Sriraman, Smriti Vaswani, Vikas Oswal, Sudha Rao, Nerges Mistry   +5 more
doaj   +1 more source

Tree species, tree genotypes and tree genotypic diversity levels affect microbe-mediated soil ecosystem functions in a subtropical forest [PDF]

, 2016
Tree species identity and tree genotypes contribute to the shaping of soil microbial communities. However, knowledge about how these two factors influence soil ecosystem functions is still lacking.
Purahong, Witoon, Wubet, Tesfaye, Durka, Walter, Schöps, Ricardo, Buscot, François, Fischer, Markus, Dommert, Sven   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Assessing Phenotypic and Genotypic Resistance to Flumethrin in Varroa destructor Populations in Muğla, Türkiye

Insects
Beekeepers use a variety of methods to control Varroa destructor (varroa). Chemical control relies heavily on flumethrin, amitraz, coumaphos, and tau-fluvalinate products.
Ali Sorucu, Bekir Çöl, Esra Dibek, Anara Babayeva   +3 more
doaj   +1 more source

The Current Status of Germplum Database: a Tool for Characterization of Plum Genetic Resources in Romania

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Horticulture, 2016
In Romania, Prunus genetic resources are kept in collections of varieties, populations and biotypes, mainly located in research and development institutes or fruit growing stations and, in the last years, by some private enterprises.
Monica Harta, Cristian Radu Sisea, Rodica Pop, Katalin Szabo, Maria Zanescu, Doina Clapa, Dorottya Domokos, Mihai Botu, Doru Pamfil   +8 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genotypic analysis of G6PD deficiency.

, 2022
Genotypic analysis of G6PD deficiency.
Thanyapit Thita (10820381), Usa Boonyuen (2548708), Sirapapha Sudsumrit (13985502), Kamonwan Chamchoy (13985505), Srivicha Krudsood (17232), Rapatbhorn Patrapuvich (278414)   +5 more
core   +1 more source