Results 71 to 80 of about 189,911 (267)

Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection [PDF]

, 2015
Small colony variant (SCV) bacteria arise spontaneously within apparently homogeneous microbial populations, largely in response to environmental stresses, such as antimicrobial treatment.
Tucker, Nicholas P., Tucker, Nicholas, Maddocks, Sarah Elizabeth, Johns, Benjamin, Maddocks, Sarah E., Purdy, Kevin J., Johns, Benjamin E.   +6 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins.

, 1998
The genetic analysis of oocysts recovered from the stools of humans and animals infected with Cryptosporidium parvum has consistently shown the existence of two distinct genotypes.
Tzipori, S., Spano, F., Morgan, U.M., Le Blancq, S.M., Tchack, L., Putignani, L., Widmer, G., Crisanti, A., Sallicandro, P.   +8 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits

Nature Communications
Characterization of the genetic and molecular architecture underlying egg production traits in chickens is essential for improving the rate of genetic gain through intensive artificial selection.
Di Zhu, Kai Shi, The ChickenGTEx Consortium, Chong Li, Yidan Yan, Houcheng Li, Zhonghao Bai, Lizhi Tan, Dailu Guan, Yiqiang Zhao, Yuzhe Wang, Baoliang Fan, Ziqin Jiang, Zhenqiang Xu, Chungang Feng, Lingzhao Fang, Xiaoxiang Hu   +16 more
doaj   +1 more source

Genotypic resistance profiles in Chinese patients with chronic hepatitis B virus infection and the efficacy of nucleoside analog rescue therapy

, 2015
Ling-Bo Liang, Lan-Lan Chen, En-Qiang Chen, Juan Liao, Hong Tang Center of Infectious Disease, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, People’s Republic of China ...
Liao J, Liang LB, Chen EQ, Chen LL, Tang H   +4 more
core  

Intercross Genotypic Ratios.

, 2013
Intercross Genotypic Ratios.
Susan Marino (30809), Roel Nusse (30810)
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Identification of invasive filamentous mold isolates using DNA sequencing: Experience of a clinical laboratory in a resource-limited setting

Biomedical and Biotechnology Research Journal
Background: Correct identification of clinically significant mold is becoming critical and cannot be relied only on phenotypic methods; hence, there is a dire need to develop an algorithm of workflows and capacity for molecular identification. This study
Seema Irfan, Mohammad Zeeshan, Najia Ghanchi, Kausar Jabeen, Afia Zafar   +4 more
doaj   +1 more source

Genotypic data and DNA concentrations

, 2013
Excel spread sheet containing the following data: Genotypic and DNA concentration Data for the scat collection and storage experiment (41 samples).
Faye Wedrowicz (3242955), Mawar Karsa (469957), Hogan, Fiona E., Wedrowicz, Faye, Mosse, Jennifer, Karsa, Mawar, Fiona E. Hogan (3242958), Jennifer Mosse (411597)   +7 more
core   +1 more source