Results 81 to 90 of about 189,911 (267)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Helicobacter pylori resistance in Hainan Province, China: investigating phenotypes and genotypes through whole-genome sequencing

Frontiers in Cellular and Infection Microbiology
Helicobacter pylori is increasingly resistant to antibiotics, significantly lowering eradication rates and posing a major public health challenge. This study investigated the distribution of antibiotic-resistant phenotypes and genotypes of H.
Yan-Ting Lv, Da Li, Da-Ya Zhang, Shi-Ju Chen, Run-Xiang Chen, Yang Wang, Wei-Zhong Yang, Lei Gao, Jun-Tao Zeng, Jian-Xin Xiong, Qiu-Ya Huang, Jing Huang, Qiao-Guan Zhang, Jia-Jia Chen, Fei-Hu Bai, Fei-Hu Bai   +15 more
doaj   +1 more source

Genotypic association of rs2227306.

, 2013
Genotypic association of rs2227306.
Luigi Tonino Marsella (424004), Giovanni Staurenghi (423998), Paola Borgiani (424003), Andrea Cusumano (424006), Emiliano Giardina (424007), Giuseppe Novelli (76046), Raffaella Cascella (424002), Tiziana Lepre (423999), Stefania Zampatti (424001), Federico Ricci (423997), Chiara Maria Eandi (424005), Filippo Missiroli (424000)   +11 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pooled genotypic proportions.

, 2018
Pooled genotypic proportions.
Getachew Tadesse (3281049), Tesfaye S. Tessema (4846672), Getenet Beyene (3432986), Abraham Aseffa (108981)   +3 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Determination of genotypic and clinical characteristics of Colombian patients with mucopolysaccharidosis IVA

, 2018
Sandra M Tapiero-Rodriguez,1 Johanna C Acosta Guio,1 Gloria Liliana Porras-Hurtado,2 Natalia García,3 Martha Solano,4 Harry Pachajoa,5 Harvy M Velasco1 1Universidad Nacional de Colombia, Departamento de morfología, Maestría de gen ...
Velasco HM, Porras-Hurtado GL, Solano M, Pachajoa H, García N, Tapiero-Rodriguez SM, Acosta Guio JC   +6 more
core  

Heterogeneity of genotypic proportions.

, 2018
Heterogeneity of genotypic proportions.
Getachew Tadesse (3281049), Tesfaye S. Tessema (4846672), Getenet Beyene (3432986), Abraham Aseffa (108981)   +3 more
core   +1 more source

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source