Results 131 to 140 of about 2,721,776 (301)

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Correlation and Simple Linear Regression

, 2012
This presentation covers correlation and simple linear regression. It contains many graphs and images to illustrate points and begins to introduce the generalised linear model through teaching students 'how to draw a line'.
Dr Luke Sloan
core  

Path analysis and expected response in indirect selection for grain yield in soybean

Crop Breeding and Applied Biotechnology, 2006
This study aimed to determine the best auxiliary trait for indirect selection of soybean grain yield, through path analysis and in avoidance of the adverse effects of multicollinearity and expected response.
Ivana Marino B·rbaro, Maria Aparecida Pessôa da Cruz Centurion, Antonio Orlando Di Mauro, Sandra Helena UnÍdaTrevisoli, Nair Helena Castro Arriel, Marcelo Marchi Costa   +5 more
doaj  

METHODS FOR KINO EVALUATION AND ESTIMATES OF GENETIC PARAMETERS IN Corymbia

Revista Árvore
Species within the genus Corymbia are regarded as potential alternatives to Eucalyptus. In addition to having superior wood quality, Corymbia spp. are tolerant to most pests, diseases, and abiotic stresses that affecting Eucalyptus plantations, including
Michele Brandão Damacena, Rodrigo Alves, Gleison Augusto dos Santos, Leonardo Lopes Bhering, Genaina Aparecida de Souza, Karine Fernandes Caiafa, Caio Varonill de Almada Oliveira, Ana Luiza Machado Gouvêa   +7 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Appendix D. Correlations between measured O. biennis traits and ecosystem processes, and a figure showing the genotypic correlation between substrate induced respiration and two leaf chemical traits.

, 2016
Correlations between measured O. biennis traits and ecosystem processes, and a figure showing the genotypic correlation between substrate induced respiration and two leaf chemical ...
Nathan Basiliko (1928779), Marney E. Isaac (2929917), Marc T. J. Johnson (117231), Connor R. Fitzpatrick (2929923), Anurag A. Agrawal (532455), Amy P. Hastings (2929914), Michael Preston (2929920)   +6 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Correlation coefficients between genotypic heterozygosity and trait performance in F_{2: 3} and F_{2: 4} populations.

, 2015
Correlation coefficients between genotypic heterozygosity and trait performance in F2: 3 and F2: 4 populations.
Jinping Hua (146024), Yumei Wang (128815), Qingzhi Liang (789537), Lianguang Shang (831676)   +3 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source