, 2023 Posterior means the standard deviation (SD) and the 95% HPD intervals (LL: lower limit, LU: upper limit) for components of variance genotypic (σg2) and residual (σe2) for models with conditional and response responses.
Carlos Pereira da Silva (7300925) +5 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Biplots of genotypic principal components.
, 2019 The first and second principal components of the SNP matrix were plotted against each other, using (A) all SNPs that passed initial filtering parameters, and (B) a thinned subset of SNPs selected to be in approximate linkage equilibrium, so that no pair ...
Priyanka Tyagi (3961991) +6 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Characterization of cultivated pumpkin (Cucurbita moschata Duchesne) landraces for genotypic variance, heritability and agro-morphological traits. [PDF]
Saudi J Biol Sci, 2022 Ezin V, Gbemenou UH, Ahanchede A.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Combined BLUP selection indexes with parents and F2 populations in soybean (Glycine max) breeding
Crop Breeding and Applied Biotechnology, 2023 This study aimed to apply selection indexes in situations in which F2 populations and their parents are evaluated simultaneously in field trials to predict population genotypic values and selecting the best populations.
André Ricardo Gomes Bezerra +6 more
doaj
Accurate determination of genotypic variance of cell wall characteristics of a Populus trichocarpa pedigree using high-throughput pyrolysis-molecular beam mass spectrometry. [PDF]
Biotechnol Biofuels, 2021 Harman-Ware AE +8 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source