Results 71 to 80 of about 43,318 (306)

Genetic Architecture of Cereal Leaf Beetle Resistance in Wheat

Plants, 2020
Wheat production can be severely damaged by endemic and invasive insect pests. Here, we investigated resistance to cereal leaf beetle in a panel of 876 winter wheat cultivars, and dissected the genetic architecture underlying this insect resistance by ...
Tobias Würschum, Willmar L. Leiser, Simon M. Langer, Matthew R. Tucker, Thomas Miedaner   +4 more
doaj   +1 more source

BIGFAM - variance components analysis from relatives without genotype

Nature Communications
Abstract Estimating variance components of phenotypes provides a fundamental basis for understanding complex traits. However, most existing methods require genotype data, which is costly to obtain and often unavailable, limiting their scalability.
Jaeeun Jerry Lee, Buhm Han
openaire   +2 more sources

Mitochondrial DNA (mtDNA) copy number and genotypic variance throughout development in germ and somatic cells of mammals.

, 2013
Although mtDNA genotypic variance in somatic cells increases early during development due to cellular differentiation, according to recent findings this will only occur later in germ-line development, during folliculogenesis that takes place after birth.
Ian J. Holt (362575), Marcos R. Chiaratti (362570), Stephen Kennedy (362574), Dagan Wells (301431), Flávio V. Meirelles (362572), Joanna Poulton (81462)   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genetic parameters and selection of sugarcane in early selection stages for resistance to sugarcane borer Diatraea saccharalis

Crop Breeding and Applied Biotechnology, 2019
A T1 (sugarcane population originating from true seeds) and T2 (first sugarcane clonal stage) population were used to estimate genetic parameters and compare selection strategies for Diatraea saccharalis (Lepidoptera: Crambidae) resistance in sugarcane ...
Adriano Cirino Tomaz, Cleiton Antonio Wartha, Marcos Deon Vilela de Resende, Bruno Portela Brasileiro, Luiz Alexandre Peternelli, Márcio Henrique Pereira Barbosa   +5 more
doaj  

A study on the minimum number of loci required for genetic evaluation using a finite locus model

Genetics Selection Evolution, 2004
For a finite locus model, Markov chain Monte Carlo (MCMC) methods can be used to estimate the conditional mean of genotypic values given phenotypes, which is also known as the best predictor (BP).
Fernando Rohan L, Totir Liviu R, Dekkers Jack CM, Fernández Soledad A   +3 more
doaj   +1 more source

Genetic variance and genotype reaction norms in response to larval food manipulation for a trait important in scorpionfly sperm competition.

, 2008
Engqvist L. Genetic variance and genotype reaction norms in response to larval food manipulation for a trait important in scorpionfly sperm competition. Functional Ecology. 2008;22(1):070915213639001-???Sperm competition is an important attribute of many
L. Engqvist, Engqvist, Leif ; https://orcid.org/   +1 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

How to deal with genotype uncertainty in variance component quantitative trait loci analyses

Genetics Research, 2011
SummaryDealing with genotype uncertainty is an ongoing issue in genetic analyses of complex traits. Here we consider genotype uncertainty in quantitative trait loci (QTL) analyses for large crosses in variance component models, where the genetic information is included in identity-by-descent (IBD) matrices.
Xia, Shen, Lars, Rönnegård, Orjan, Carlborg   +2 more
openaire   +2 more sources