Results 61 to 70 of about 43,318 (306)

Phenotypic variance explained by genotypic variation.

, 2012
(A) Total explained variance for genetically controlled parameters (x axis) using detected causal SNPs as predictors. (B) Total explained variance for cellular phenotypes (x axis) using detected causal SNPs obtained from GWAS targeting these phenotypes. (
Peter J. Hunter (172948), Yunpeng Wang (172933), Arne B. Gjuvsland (172936), Jon Olav Vik (172940), Nicolas P. Smith (172944), Stig W. Omholt (152641)   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Genetic variability, correlation and path analysis in mango ginger (Curcuma amada ROXB.)

Electronic Journal of Plant Breeding, 2022
The present investigation was carried out at the Research Farm, Department of Genetics and Plant Breeding, Navsari Agricultural University, Navsari, Gujarat during the kharif, 2018. Twelve different quantitative characters related to rhizome yield were
Raval Kalpesh*, R. K. Patel, Rajesh Panchal and K. G. Modha
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genetic variability and character association in bread wheat (Triticum aestivum)

The Indian Journal of Agricultural Sciences, 2014
Forty seven released varieties of common bread wheat (Triticum aestivum L.) were evaluated during rabi 2007-08 to 2010-11 for four years under irrigated conditions at Directorate of Seed Research, Mau.
H S MEENA, DINESH KUMAR, S RAJENDRA PRASAD   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Combining Ability, Heritability and Genetic Variance in Tomato (Lycopersicon lycopersicum) Genotypes

Asian Journal of Agricultural and Horticultural Research, 2022
A study was conducted to determine gene actions controlling yield and other qualitative traits of tomato (Lycopersicon lycopersicum) as well as combining ability among selected genotypes at the Teaching and Research Farm of the Ladoke Akintola University of Technology, Ogbomoso during the 2017 and 2018 cropping seasons.
M. N. Iliya, C. O. Aremu, A. O. Kolawole, L. Oladokun, D. O. Ibirinde   +4 more
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Genetic variability, heritability, correlation and path analysis in snake gourd (Trichosanthes cucumerina L.)

Electronic Journal of Plant Breeding, 2017
The present investigation was conducted to magnitude the genetic variability, heritability and genetic advance in snake gourd for identifying desirable parents. Fifty genotypes were evaluated for eleven characters through RBD during the year 2011–12. The
N. Deepa Devi, S. Mariappan, T. Arumugam and, C.R. Anandakumar   +3 more
doaj   +1 more source