Results 121 to 130 of about 554,185 (237)

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang, Yunjun Li, Di Han, Kun Deng, Wei Gao, Minghua Wu   +5 more
wiley   +1 more source

Sustainability in the laboratory: evaluating the reusability of microtitre plates for PCR and fragment detection. [PDF]

R Soc Open Sci
Berthelsen AL, Paijmans AJ, Forcada J, Hoffman JI.   +3 more
europepmc   +1 more source

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Advanced Science, EarlyView.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng   +10 more
wiley   +1 more source

Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants. [PDF]

Fam Cancer
Ala-Kulju K, Carpén O, Lappalainen M, Pehrsson M.   +3 more
europepmc   +1 more source

Genotyping: What Applied Economists Should Know [PDF]

Livestock Production/Industries,
Bauer, Marc L., DeVuyst, Eric A., Lambert, David K.   +2 more
core   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Higher Genotyping Performance of the Applied Biosystems TaqPath Seq HIV-1 Genotyping Kit Against ViroSeq HIV-1 Genotyping Kit in HIV <i>Protease</i>, <i>Reverse Transcriptase</i>, and <i>Integrase</i> Regions. [PDF]

Infect Drug Resist
Choga OT, Okafor O, Lemogang GM, Choga WT, Muzanywa G, Garcia AE, Moyo S, Gaseitsiwe S.   +7 more
europepmc   +1 more source

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhiyi Li, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +9 more
wiley   +1 more source

Benefits of Combining Circulating Tumor DNA With Tissue and Longitudinal Circulating Tumor DNA Genotyping in Advanced Solid Tumors: SCRUM-Japan MONSTAR-SCREEN-1 Study. [PDF]

JCO Precis Oncol
Fujisawa T, Nakamura Y, Bando H, Morizane C, Ikeda M, Nonomura N, Matsubara N, Iwata H, Naito Y, Okano S, Aoki D, Harano K, Yamazaki N, Namikawa K, Ueno M, Kadowaki S, Oki E, Kato K, Komatsu Y, Satoh T, Esaki T, Denda T, Hamaguchi T, Yamazaki K, Matsuhashi N, Yasui H, Satake H, Nishina T, Takahashi N, Goto M, Sunakawa Y, Kato T, Otsuka T, Abutani H, Tukachinsky H, Lee JK, Oxnard GR, Kuramoto N, Horasawa S, Sakamoto Y, Taniguchi H, Yoshino T.   +41 more
europepmc   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source