Results 31 to 40 of about 1,163,135 (344)
Journal of Clinical Oncology, 2016 PURPOSE Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated potent activity against TKI resistance mediated by EGFR T790M.
P. Jänne +4 more
semanticscholar +1 more source
Frontiers in Medicine, 2020 Purpose: To evaluate the sensitivity and accuracy of the quadruple real-time PCR method for the detection of enterococci carrying vancomycin-resistant genes vanA, vanB, and vanM in rectal swabs.Methods: Choosing PCR-sequenced DNA extracted directly from ...
Yuanhui He +7 more
doaj +1 more source
JAMA Oncology, 2016 IMPORTANCE Plasma genotyping of cell-free DNA has the potential to allow for rapid noninvasive genotyping while avoiding the inherent shortcomings of tissue genotyping and repeat biopsies. OBJECTIVE To prospectively validate plasma droplet digital PCR (
A. Sacher +8 more
semanticscholar +1 more source
Priors for Genotyping Polyploids [PDF]
Bioinformatics, 2019 AbstractMotivationEmpirical Bayes techniques to genotype polyploid organisms usually either (i) assume technical artifacts are knowna priorior (ii) estimate technical artifacts simultaneously with the prior genotype distribution. Case (i) is unappealing as it places the onus on the researcher to estimate these artifacts, or to ensure that there are no ...
Gerard, David +1 more
openaire +4 more sources
Genotyping structural variants in pangenome graphs using the vg toolkit
Genome Biology, 2019 Structural variants (SVs) remain challenging to represent and study relative to point mutations despite their demonstrated importance. We show that variation graphs, as implemented in the vg toolkit, provide an effective means for leveraging SV catalogs ...
G. Hickey +9 more
semanticscholar +1 more source
Nature Communications, 2018 Association between variants in 11 different genes and breast cancer risk has been established and sequencing of these genes is recommended to provide personalized diagnosis, therapy, and surveillance for the high-risk patients and their relatives.
Yukihide Momozawa +14 more
doaj +1 more source
HIV: how to manage low-level viraemia in people living with HIV
Drugs in Context, 2022 Background: People living with HIV (PLWH) and receiving antiretroviral therapy (ART) have a goal of achieving and maintaining viral suppression; however, low-level viraemia (LLV) (HIV-RNA viral load levels of 50–999 copies/mL) persists in certain ...
Emily K Hanners +2 more
doaj +1 more source
False-Positive Plasma Genotyping Due to Clonal Hematopoiesis
Clinical Cancer Research, 2018 Purpose: Plasma cell-free DNA (cfDNA) genotyping is increasingly used in cancer care, but assay accuracy has been debated. Because most cfDNA is derived from peripheral blood cells (PBC), we hypothesized that nonmalignant mutations harbored by ...
Yuebi Hu +11 more
semanticscholar +1 more source
Genotyping—From Genomic DNA to Genotype in a Single Tube [PDF]
Angewandte Chemie International Edition, 2005 AbstractNucleotide variations in the human genome, such as single‐nucleotide polymorphisms, have been researched more intensively since it became apparent that these deviations are linked to various diseases and also several side effects of drugs. The investigation of genomic DNA in the laboratory requires routine methods that are time‐, labour‐, and ...
Strerath, Michael, Marx, Andreas
openaire +4 more sources
Annals of Agricultural and Environmental Medicine, 2015 Introduction During 2008–2012, a total of 466 ticks Ixodes ricinus removed from humans were collected and tested for the presence of Borrelia burgdorferi sensu lato (Bbsl).
Ondřej Bonczek +3 more
doaj +1 more source