Results 131 to 140 of about 10,219,641 (384)

Genotype networks in metabolic reaction spaces [PDF]

BMC Systems Biology, 4:30 (2010) http://www.biomedcentral.com/1752-0509/4/30/, 2010
Background: A metabolic genotype comprises all chemical reactions an organism can catalyze via enzymes encoded in its genome. A genotype is viable in a given environment if it is capable of producing all biomass components the organism needs to survive and reproduce.
arxiv  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Modified MLVA for Genotyping Queensland Invasive Streptococcus pneumoniae.

PLoS ONE, 2015
BackgroundGlobally, over 800 000 children under five die each year from infectious diseases caused by Streptococcus pneumoniae. To understand genetic relatedness between isolates, study transmission routes, assess the impact of human interventions e.g ...
Rachael E Rayner, John Savill, Louise M Hafner, Flavia Huygens   +3 more
doaj   +1 more source

Evaluation of mitochondrial DNA copy number estimation techniques

bioRxiv, 2019
Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell, is a minimally invasive proxy measure for mitochondrial function and has been associated with several aging-related diseases.
Ryan J. Longchamps, C. Castellani, Stephanie Y. Yang, Charles E Newcomb, Jason A. Sumpter, J. Lane, M. Grove, E. Guallar, N. Pankratz, K. Taylor, J. Rotter, E. Boerwinkle, D. Arking   +12 more
semanticscholar   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
A Yeka, B Greenhouse, CH Sibley, E Depoortere, Eleanor Turyakira, Elizabeth A Ashley, F Grandesso, Francesco Checchi, Grant Dorsey, H Bukirwa, Hasifa Bukirwa, I van den Broek, I Zongo, I Zongo, Ingrid van den Broek, Issaka Zongo, Jean-Paul Guthmann, JP Guthmann, JP Guthmann, JP Guthmann, K Mugittu, K Mugittu, K Stepniewska, K Stepniewska, Loretxu Pinoges, M Bonnet, Michel van Herp, N Bakyaita, NJ White, Pedro Pablo Palma Urruta, Piero Olliaro, PO Olliaro, RN Price, S Hamour, SG Staedke, Suna Balkan, TD Swarthout, Walter R Taylor, WJ Collins, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization   +43 more
core   +5 more sources

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Evaluating genotyping‐in‐thousands by sequencing as a genetic monitoring tool for a climate sentinel mammal using non‐invasive and archival samples

Ecology and Evolution
Genetic tools for wildlife monitoring can provide valuable information on spatiotemporal population trends and connectivity, particularly in systems experiencing rapid environmental change.
Kate E. Arpin, Danielle A. Schmidt, Bryson M. F. Sjodin, Anthony L. Einfeldt, Kurt Galbreath, Michael A. Russello   +5 more
doaj   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Standardization of a Molecular Technique for Human Papillomavirus Genotyping in a Public-Health Service. [PDF]

Cureus
De Souza SS, Abreu MHH, Paiva Ceribelli RM, da Silva PCN, De Oliveira GC, Roll MM.   +5 more
europepmc   +2 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source