Results 201 to 210 of about 3,783 (266)

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection

open access: yesMolecular Microbiology, EarlyView.
Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark   +11 more
wiley   +1 more source

Cyclophilin A‐mediated cis/trans isomerization modulates RIN4 to control intracellular rhizobial infection in legumes

open access: yesNew Phytologist, EarlyView.
Summary In most legume‐rhizobium symbioses, rhizobial colonization occurs through host‐derived intracellular infection threads, which enable rhizobial recruitment while presumably modulating the host immune system to prevent rejection. To investigate post‐translational regulation of immune responses during rhizobial infection, we focused on Cyclophilin
Takashi Goto   +8 more
wiley   +1 more source

Research Progress on Risk Factors for Acute Kidney Injury After Antibiotic‐Loaded Bone Cement Spacer Treatment for Periprosthetic Joint Infection

open access: yesOrthopaedic Surgery, EarlyView.
During the two‐stage revision treatment of PJI patients, the use of ALCS may lead to the development of AKI, which could result in severe adverse outcomes. Despite the wide variation in the incidence of developing AKI reported in the literature, clinicians still need adequate attention, especially when confronting PJI patients who are elderly, obese ...
Lijun Cai   +6 more
wiley   +1 more source

Hydrophilic inflatable penile prosthesis surface coatings readily rebind antibiotics and maintain antimicrobial efficacy ex vivo. [PDF]

open access: yesInt J Impot Res
Im BH   +7 more
europepmc   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song   +14 more
wiley   +1 more source

The effect of protocatechuic acid on nephrotoxicity induced by gentamicin in rats. [PDF]

open access: yesNaunyn Schmiedebergs Arch Pharmacol
Mert H, Cibuk S, Yildirim S, Mert N.
europepmc   +1 more source

A Modified Cas9 Scaffold Allows Extension of the Virus‐Induced Gene Editing Technology to the Large Potyvirus Genus

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses are recognized as rapid and effective vectors to deliver CRISPR‐Cas reaction components into plants, a strategy termed virus‐induced gene editing (VIGE). However, VIGE is limited by the host range of the viral vectors. Development of new viral vectors to target a broad range of plant species will potentially enable the delivery ...
Fernando Merwaiss   +3 more
wiley   +1 more source

The Beneficial Effect of Melatonin on Gentamicin-induced Liver Injury in Rats. [PDF]

open access: yesMed Arch
Krupalija-Fazlic M   +4 more
europepmc   +1 more source

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