Results 161 to 170 of about 1,328 (198)

Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound

Mini-Reviews in Medicinal Chemistry, 2016
Gentiopicroside is a secoiridoid compound isolated from Gentiana lutea which is called Qin Jiao in Chinese. It is one of the most common herbal medicines used in China. In this article, we review the pharmacological and biological activity (antiviral, anti-inflammatory, analgesia, antihepatotoxic and choleretic), as well as biotransformation of the ...
Wu, Shaoping, Ning, Yaoyao, Zhao, Yingyong, Sun, Wenji, Thorimbert, Serge, Dechoux, Luc, Sollogoub, Matthieu, Zhang, Yongmin   +7 more
openaire   +2 more sources

Suppression of Chemically and Immunologically Induced Hepatic Injuries by Gentiopicroside in Mice

Planta Medica, 1994
Gentiopicroside (GPS), a main bitter secoiridoid constituent of roots of Gentiana macrophylla Pall., was tested for therapeutic effects on the two hepatic injury models, the CCl4-induced and lipopolysaccharide (LPS)/bacillus Calmette-Guerin (BCG)-induced hepatitides. An increase in serum level of hepatic aminotransferases (GOT: EC 2.6.1.1.
Y, Kondo, F, Takano, H, Hojo
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Optimizing Shoot Formation in Gentiana kurroo Royle for Gentiopicroside Production

Journal of Plant Growth Regulation, 2021
The roots and shoots of Gentiana kurroo Royle are rich sources of gentiopicroside (GPD). The plant is used traditionally for curing many metabolic diseases. The exploitation of G. kurroo in its native habitat has placed the plant on the critically endangered list of plants in India. One of the ways of creating an alternative source of G.
Mariadoss Alphonse, Rajasekaran Chandrasekaran, Siva Ramamoorthy, Devanand P. Fulzele, Ravindra Raina, Kalaivani Thiagarajan   +5 more
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Gentiopicroside is Located in the Vacuoles of Root Protoplasts of Gentiana lutea

Journal of Plant Physiology, 1986
Summary Gentiopicroside, the main secoiridoid glucoside of Gentiana lutes roots, was found to be evenly distributed throughout the cross-section of the roots at a concentration of 14.7 mg/g fwt. The subcellular compartmentation of gentiopicroside was studied by isolating protoplasts and vacuoles and comparing their content.
exaly   +2 more sources

Gentiopicroside: An Updated Review of Its Pharmacological Activities and Mechanisms

Chemistry & Biodiversity
ABSTRACT Gentiopicroside (GPS) is a bioactive iridoid glycoside isolated from Gentianaceae plants. In recent years, GPS has received increasing attention due to its multiple pharmacological activities.
Yin Ding, Xiaoling Gou, Xinyue Wu, Yiwen Tao, Yaqian Wang, Yue Wang, Jingye Liu, Xianhua Zhou, Tingting Kuang, Gang Fan   +9 more
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Separation and determination of gentiopicroside and swertiamarin in Tibetan medicines by micellar electrokinetic electrophoresis

Biomedical Chromatography, 2003
AbstractMicellar electrokinetic electrophoresis was employed to determine two active components, gentiopicroside (GE) and swertiamarin (SW) in one Tibetan preparation medicine named shiweilongdankeli, two Tibetan herbal medicines named Gentiana rhodantha and Gentiana kitag and three other Chinese Gentiana medicines named Gentiana scabra, Gentiana ...
Shengguo, Zhao, Qing, Liu, Xingguo, Chen, Zhide, Hu   +3 more
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Pharmacokinetics and tissue distribution of Gentiopicroside following oral and intravenous administration in mice

European Journal of Drug Metabolism and Pharmacokinetics, 2004
The pharmacokinetics and tissue distribution of Gentiopicroside (GPS), one of the major active components of the Gentiana species of medicinal plants, was studied following oral and intravenous administration in mice. The distribution of GPS in mice after oral and intravenous doses could be fitted to a two-compartments open model.
Chang-Hong, Wang, Zheng-Tao, Wang, S W Annie, Bligh, Kenneth N, White, Christopher J Branford, White   +4 more
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Studies on Iridoid-related Compounds III: Gentiopicral, the Aglucone of Gentiopicroside

Planta Medica, 1983
Enzymatic hydrolysis of gentiopicroside ( 1) provided the new aglucone, gentiopicral ( 2), the structure of which was firmly elucidated by means of spectroscopic methods.
K, Ishiguro, M, Yamaki, S, Takagi
exaly   +3 more sources

Changes of Gentiopicroside Synthesis during Somatic Embryogenesis inGentiana macrophylla

Planta Medica, 2009
IN VITRO plant regeneration of Gentiana macrophylla Pall. and determination of gentiopicroside content during somatic embryogenesis are described in the present work. The highest percentage of embryogenic callus formation was observed in Murashige and Skoog (MS) medium supplemented with 1.0 mg/L 2,4-dichlorophenoxyacetic acid (2,4-D) and 1.0 mg/L 6 ...
Chen, Li-Yu, Chen, Qian-Liang, Xu, Dan, Hao, Jian-Gao, Schläppi, Michael, Xu, Zi-Qin   +5 more
openaire   +3 more sources

Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1

Phytomedicine
The suppression of the fibroblast growth factor 21/fibroblast growth factor receptor 1 (FGF21/FGFR1) signaling pathway is considered as a vital factor in the type 2 diabetes mellitus (T2DM) progression. Our previous study showed that gentiopicroside (GPS), the main active compound present in Gentiana macrophylla Pall., has the capacity to control ...
Zhanchi, Xu, Jucun, Huang, Min, Wen, Xuting, Zhang, Dongxin, Lyu, Shanshan, Li, Haiming, Xiao, Min, Li, Cuangpeng, Shen, Heqing, Huang   +9 more
openaire   +2 more sources