Results 171 to 180 of about 1,328 (198)

Identification of bio‐active metabolites of gentiopicroside by UPLC/Q‐TOF MS and NMR

Biomedical Chromatography, 2013
ABSTRACTGentiopicroside (GPS), the main bioactive component in Gentiana scabra Bge., has attracted our attention owing to its high bioactivity, especially the treatment of hepatobiliary disorders. The aglycone form of GPS, a typical secoiridoid glycoside, is considered to be more readily absorbed than its parent drug.
Wenliang, Zeng, Han, Han, Yanyan, Tao, Li, Yang, Zhengtao, Wang, Kaixian, Chen   +5 more
openaire   +2 more sources

[Studies on the metabolism of gentiopicroside by rat intestinal flora].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003
To study the metabolism of gentiopicroside by rat intestinal flora in vitro and time profiles of gentiopicroside and its metabolites in rat serum after oral administration of gentiopicroside.Using high performance liquid chromatography (HPLC) for determination of gentiopicroside, gentianine and gentianal content of rat intestinal flora culture medium ...
X F, Yang, C Q, Song
openaire   +1 more source

Smooth Muscle Relaxing Activity of Gentiopicroside Isolated from Gentiana spathacea

Planta Medica, 2000
Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of isolated guinea pig ileum ...
A, Rojas, M, Bah, J I, Rojas, D M, Gutiérrez   +3 more
openaire   +2 more sources

[Content of gentiopicroside and loganic acid in Radix gentianae and their fingerprints].

Yao xue xue bao = Acta pharmaceutica Sinica, 2009
To develop a HPLC-DAD-ESI-TOF/MS analysis method for the determination of gentiopicroside and loganic acid in Radix gentianae samples and for the research of their fingerprints. The samples were extracted using ASE for 10 min under 100 degrees C and 9.65 MPa, and divided into water phase and chloroform phase and analyzed them with HPLC-DAD-ESI-TOF/MS ...
Wen-Long, Li, Jun-Hui, Chen, Yue-Fen, Yin, Feng-Qi, Wu, Bai-Juan, Yang, Huang-Hao, Yang, Xiao-Ru, Wang   +6 more
openaire   +1 more source

In Vitro Transformations of Gentiopicroside and Swertiamarin

Journal of Natural Products, 1988
S S, Popov, N L, Marekov, T N, Do
openaire   +2 more sources

Biosynthesis of Gentiopicroside, a Novel Monoterpene

Journal of the American Chemical Society, 1967
C J, Coscia, R, Guarnaccia
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Gentiopicroside attenuates lupus arthritis by targeting galectin-mediated macrophage activation

Phytomedicine
Inflammatory arthritis represents a common and clinically challenging manifestation of systemic lupus erythematosus (SLE), with current therapeutic options often exhibiting limited efficacy.This study aimed to investigate the anti-arthritic effects and underlying mechanism of gentiopicroside (GPS), a key bioactive constituent of the Jiawei Baihu Jia ...
Yihong Gan, Shihui Zhou, Ke Lin, Yijing Bai, Jingqun Liu, Meng Jin, Shuo Huang, Qice Sun, Chao Sun, Yilin Zhang, Shengyu Chen, Xinchang Wang, Yongsheng Fan, Jie Bao, Li Xu   +14 more
openaire   +2 more sources

[Callus cultivation and determination of gentiopicroside from Gentiana macrophylla].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2013
To explore and improve the utilization efficiency of Gentiana macrophylla resources.The germination of Gentiona macrophylla seeds were used as explants to induce calluses; Cultured on various culture media and condition for callus induction and subculture by test; The content of gentiopicroside in callus was determined by HPLC.The optimum medium for ...
Qian, Hou, Mei, Guo, Fan, Zhang, Jin-xia, Zhou, Li-sha, Liu   +4 more
openaire   +1 more source

Fungitoxic Activity of the Secoiridoid Glucoside Gentiopicrin (Gentiopicroside)

Planta Medica, 1981
W G, van der Sluis, R P, Labadie
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[Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014
To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside.The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC.
Bo, Feng, He-Yun, Zhu, Jiao, Guan, Cheng-Yi, Hao, Jing-Can, Duan, Jing-Kai, Gu   +5 more
openaire   +1 more source