Results 31 to 40 of about 21,775 (287)
Treating patients with geographic atrophy: are we there yet?
International Journal of Retina and Vitreous, 2023 Geographic atrophy (GA) is a progressive degenerative disease that significantly contributes to visual impairment in individuals aged 50 years and older. The development of GA is influenced by various modifiable and non-modifiable risk factors, including
Bani Antonio-Aguirre +1 more
doaj +1 more source
Investigational drugs inhibiting complement for the treatment of geographic atrophy.
, 2023 INTRODUCTION Geographic atrophy (GA) is a progressive form of age-related macular degeneration (AMD) that leads to severe visual impairment and central vision loss.
Ferro Desideri, Lorenzo +6 more
core +1 more source
Choriocapillaris Degeneration in Geographic Atrophy [PDF]
The American Journal of Pathology, 2019 Early age-related macular degeneration (AMD) is characterized by degeneration of the choriocapillaris, the vascular supply of retinal photoreceptor cells. We assessed vascular loss during disease progression in the choriocapillaris and larger vessels in the deeper choroid.
Elliott H. Sohn +11 more
openaire +2 more sources
Living with Geographic Atrophy: An Ethnographic Study
Ophthalmology and Therapy, 2019 Introduction The specific impact from the patient’s perspective of geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), is not well understood.
Sobha Sivaprasad +7 more
doaj +1 more source
Methodological Appraisal of Phase 3 Clinical Trials in Geographic Atrophy
Biomedicines, 2023 Geographic atrophy (GA) secondary to age-related macular degeneration is a common cause of blindness worldwide. Given the recent approval of the first therapy for GA, pegcetacoplan, we critically appraise methodological aspects of the phase 3 clinical ...
Marc Biarnés +8 more
doaj +1 more source
Autofluorescence Lifetimes in Geographic Atrophy in Patients With Age-Related Macular Degeneration. [PDF]
, 2016 PURPOSE To investigate fluorescence lifetime characteristics in patients with geographic atrophy (GA) in eyes with age-related macular degeneration and to correlate the measurements with clinical data and optical coherence tomography (OCT) findings.
Dysli, Chantal-Simone +2 more
core +1 more source
Indian Journal of Ophthalmology, 2015 Purpose: To provide a detailed analysis of age-related macular degeneration (AMD) with a 5-year follow-up at a Tertiary Eye Care Center in India. Methods: In this retrospective institutional study, 408 eyes of 204 subjects (100 males) with a diagnosis of
Aditya Sudhalkar +5 more
doaj +1 more source
A role for mast cells in geographic atrophy [PDF]
The FASEB Journal, 2020 Abstract Mast cells (MCs) are the initial responders of innate immunity and their degranulation contribute to various etiologies. While the abundance of MCs in the choroid implies their fundamental importance in the eye, little is known about the significance of MCs and their degranulation in choroid.
Shuntaro, Ogura +8 more
openaire +2 more sources
MMP-2 Rs24386 (C-->T) gene polymorphism and the phenotype of age-related macular degeneration [PDF]
International Journal of Ophthalmology, 2017 AIM: To examine the MMP-2 (-1306 C/T) gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration (AMD) and geographic atrophy of late AMD form.
Rasa Liutkeviciene +6 more
doaj +1 more source
Multimodal imaging of geographic atrophy.
, 2016 (A) (B) Numerous reticular pseudodrusen and depigmentation of macular area were seen on color fundus photography. (C) (D) Fundus autofluorescence revealed hypoautofluorescence corresponding to geographic atrophy.
Seigo Yoneyama (2503747) +8 more
core +1 more source