Results 21 to 30 of about 706,442 (245)

Is There a Relationship Between Use of Anti-Vascular Endothelial Growth Factor Agents and Atrophic Changes in Age-Related Macular Degeneration Patients?

Türk Oftalmoloji Dergisi, 2018
Choroidal neovascularization due to age-related macular degeneration (AMD) is currently treated successfully with anti-vascular endothelial growth factor (VEGF) intravitreal agents.
Süleyman Kaynak, Mahmut Kaya, Derya Kaya   +2 more
doaj   +1 more source

Serum lipids in adults with late age-related macular degeneration: a case-control study

Lipids in Health and Disease, 2019
Background Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized.
Richard D. Semba, Ruin Moaddel, Mary Frances Cotch, Fridbert Jonasson, Gudny Eiriksdottir, Tamara B. Harris, Lenore J. Launer, Kai Sun, Ronald Klein, Debra A. Schaumberg, Pálmi Jónsson, Vilmundur Gudnason, Luigi Ferrucci   +12 more
doaj   +1 more source

Test–retest variability of microperimetry in geographic atrophy

International Journal of Retina and Vitreous, 2020
Purpose Microperimetry (MP) allows for measurement of retinal sensitivity at precise locations and is now commonly employed as a clinical trial endpoint.
A. Yasin Alibhai, Nihaal Mehta, Sheila Hickson-Curran, Carlos Moreira-Neto, Emily S. Levine, Elias Reichel, Jay S. Duker, Nadia K. Waheed   +7 more
doaj   +1 more source

Treating patients with geographic atrophy: are we there yet?

International Journal of Retina and Vitreous, 2023
Geographic atrophy (GA) is a progressive degenerative disease that significantly contributes to visual impairment in individuals aged 50 years and older. The development of GA is influenced by various modifiable and non-modifiable risk factors, including
Bani Antonio-Aguirre, J. Fernando Arevalo   +1 more
doaj   +1 more source

Gray matter atrophy rate as a marker of disease progression in AD [PDF]

, 2010
Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using: (1) nonlinear registration and integration of Jacobian values ...
Miller, David H., Nick C. Fox, Kelvin K. Leung, David H. Miller, Anderson, V.M., Anderson, Valerie M, Jonathan W. Bartlett, Leung, Kelvin K, Bartlett, J.W., Bartlett, Jonathan W., Leung, Kelvin K., Fox, Nick C, Schott, Jonathan M, Leung, K.K., Fox, Nick C., Schott, Jonathan M., Valerie M. Anderson, Fox, N.C., Anderson, Valerie M., Schott, J.M., Bartlett, Jonathan W, Jonathan M. Schott, Miller, David H, Miller, D. H., Schott, JM, Fox, NC, Leung, KK, Miller, DH, Anderson, Valerie, Bartlett, JW   +29 more
core   +1 more source

Living with Geographic Atrophy: An Ethnographic Study

Ophthalmology and Therapy, 2019
Introduction The specific impact from the patient’s perspective of geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), is not well understood.
Sobha Sivaprasad, Elizabeth A. Tschosik, Robyn H. Guymer, Audrey Kapre, Ivan J. Suñer, Antonia M. Joussen, Paolo Lanzetta, Daniela Ferrara   +7 more
doaj   +1 more source

[Imaging diagostics of geographic atrophy] [PDF]

, 2010
The development of imaging technologies has contributed to the understanding of the genesis and pathophysiological mechanisms of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).
Wolf, S, M. Fleckenstein, Wolf-Schnurrbusch, U, von Strachwitz, C, S. Wolf, Schmitz-Valckenberg, S, U. Wolf-Schnurrbusch, Holz, F G, Fleckenstein, M, F.G. Holz, C. von Strachwitz, S. Schmitz-Valckenberg   +11 more
core   +1 more source

Development of Therapies for Spinal Muscular Atrophy Using Gene Therapy and Nanotechnology [PDF]

, 2013
Spinal muscular atrophy (SMA) is a genetic disease which is characterized by muscle weakness and atrophy. The disease arises from mutations in the survival motor neuron 1 (SMN1) gene causing degeneration of spinal cord motor neurons.
Little, Daniel
core   +6 more sources

Retrospective hospital-based analysis of age-related macular degeneration patterns in India: 5-year follow-up

Indian Journal of Ophthalmology, 2015
Purpose: To provide a detailed analysis of age-related macular degeneration (AMD) with a 5-year follow-up at a Tertiary Eye Care Center in India. Methods: In this retrospective institutional study, 408 eyes of 204 subjects (100 males) with a diagnosis of
Aditya Sudhalkar, Vaibhav Sethi, Priyanka Gogte, Sailaja Bondalapati, Mitali Khodani, Jay Kumar Chhablani   +5 more
doaj   +1 more source

Methodological Appraisal of Phase 3 Clinical Trials in Geographic Atrophy

Biomedicines, 2023
Geographic atrophy (GA) secondary to age-related macular degeneration is a common cause of blindness worldwide. Given the recent approval of the first therapy for GA, pegcetacoplan, we critically appraise methodological aspects of the phase 3 clinical ...
Marc Biarnés, Xavier Garrell-Salat, Alba Gómez-Benlloch, Mercè Guarro, Gabriel Londoño, Elena López, Sergi Ruiz, Meritxell Vázquez, Laura Sararols   +8 more
doaj   +1 more source