Results 51 to 60 of about 1,535,618 (326)

Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]

, 2013
BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Bastawrous, Andrew, Foster, Allen, Kuper, Hannah, Leung, Irene, Mathenge, Wanjiku, Peto, Tunde   +5 more
core   +6 more sources

Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months

JAMA ophthalmology
Key Points Question What is the association between intravitreal pegcetacoplan and consensus spectral domain optical coherence tomography features of geographic atrophy?
D. J. Fu, Pallavi Bagga, Gunjan Naik, S. Glinton, Livia Faes, B. Liefers, Rosana Lima, Georgina Wignall, P. Keane, Estelle Ioannidou, A. P. Ribeiro Reis, A. McKeown, Lukas Scheibler, Praveen J. Patel, Ismail Moghul, N. Pontikos, Konstantinos Balaskas   +16 more
semanticscholar   +1 more source

The effect of non-neovascular age-related macular degeneration on face recognition performance [PDF]

, 2018
PURPOSE: There is a well-established research base surrounding face recognition in patients with age-related macular degeneration (AMD). However, much of this existing research does not differentiate between results obtained for 'wet' AMD and 'dry' AMD ...
Binns, A. M., Crabb, D. P., Smith, N. D., Taylor, D. J.   +3 more
core   +2 more sources

C5 inhibitor avacincaptad pegol treatment for geographic atrophy: A comprehensive review

Immunotherapy
Geographic atrophy (GA) remains a leading cause of central vision loss with no known cure. Until recently, there were no approved treatments for GA, often resulting in poor quality of life for affected patients. GA is characterized by atrophic lesions on
Carl J. Danzig, A. Khanani, Anat Loewenstein   +2 more
semanticscholar   +1 more source

Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]

, 2012
The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Birke, Kerstin, Burger, Johannes, Welge-Lussen, Ulrich, Yu, Alice L.   +3 more
core   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The Association Between Metformin Use and New-Onset ICD Coding of Geographic Atrophy

Investigative Ophthalmology and Visual Science
Purpose Metformin has been suggested to protect against the development of age-related macular degeneration (AMD) in multiple observational studies. However, the association between metformin and geographic atrophy (GA), a debilitating subtype of AMD ...
J. Moir, Max J. Hyman, Reem Gonnah, Andrea Flores, S. Hariprasad, D. Skondra   +5 more
semanticscholar   +1 more source

Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers. [PDF]

, 2016
PurposeWe determined the phenotypic variation, disease progression, and potential modifiers of autosomal dominant retinal dystrophies caused by a splice site founder mutation, c.828+3A>T, in the PRPH2 gene.MethodsA total of 62 individuals (19 families)
Birch, David G, Bowne, Sara J, Conneely, Karen N, Daiger, Stephen P, Hughbanks-Wheaton, Dianna K, Shankar, Suma P, Stone, Edwin M, Sullivan, Lori S   +7 more
core  

Morphometric analyses of the visual pathways in macular degeneration

, 2014
Introduction. Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated.
Baseler, Heidi A., Cornelissen, Frans W., Gouws, Andre, Greenlee, Mark W., Hernowo, Aditya T., Hooymans, Johanna M. M., Morland, Antony B., Plank, Tina, Prins, Doety   +8 more
core   +2 more sources

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source