Results 51 to 60 of about 1,107,546 (279)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On approximating the quasi-arithmetic mean
Journal of Inequalities and Applications, 2019 In this article, we prove that the double inequalities α1[7C(a,b)16+9H(a,b)16]+(1−α1)[3A(a,b)4+G(a,b)4]
Tie-Hong Zhao +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The geometric mean of two matrices from a computational viewpoint [PDF]
, 2011 The geometric mean of two matrices is considered and analyzed from a computational viewpoint. Some useful theoretical properties are derived and an analysis of the conditioning is performed.
Iannazzo, Bruno
core
On the Geometric Mean Operator
Journal of Mathematical Analysis and Applications, 1994 The authors give a characterization of pairs of weights \((u,v)\) such that the geometric mean operator \(Gf(x)= \exp((1/x) \int_ 0^ x \log f(t) dt)\), defined for \(f>0\) almost everywhere on \((0,\infty)\), is bounded from \(L_{p,v} (0,\infty)\) to \(L_{q,u} (0,\infty)\), where \(01\) the good weights for \(G\) coincide with those good for the ...
Pick, L., Opic, B.
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Assessing Standard Error Estimation Approaches for Robust Mean-Geometric Mean Linking
AppliedMathRobust mean-geometric mean (MGM) linking methods enable reliable group comparisons in item response theory models under fixed and sparse differential item functioning.
Alexander Robitzsch
doaj +1 more source
Geometric phases for wave packets in a uniform magnetic field
, 2002 A wave packet of a charged particle always make cyclic circular motion in a uniform magnetic field, just like a classical particle. The nonadiabatic geometric phase for an arbitrary wave packet can be expressed in terms of the mean value of a number ...
Aharonov +23 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A Refinement of Jensen's Discrete Inequality for Differentiable Convex Functions [PDF]
, 2002 A refinement of Jensen’s discrete inequality and applications for the celebrated Arithmetic Mean – Geometric Mean – Harmonc Mean inequality and Cauchy-Schwartz-Bunikowski inequality are pointed ...
Dragomir, Sever S, Scarmozzino, F. P
core