Results 61 to 70 of about 4,553,166 (289)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Assessing Standard Error Estimation Approaches for Robust Mean-Geometric Mean Linking
AppliedMathRobust mean-geometric mean (MGM) linking methods enable reliable group comparisons in item response theory models under fixed and sparse differential item functioning.
Alexander Robitzsch
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
The perils of measuring biodiversity responses to habitat change using mixed metrics
Conservation Letters, 2023 Existing quantitative syntheses on how biodiversity responds to anthropogenic habitat change appear to sometimes mix different biodiversity metrics in drawing inferences.
Mingxin Liu, Xinran Miao, Fangyuan Hua
doaj +1 more source
FEBS Open Bio, EarlyView.The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley +1 more source
Clustering Signed Networks with the Geometric Mean of Laplacians [PDF]
, 2016 Signed networks allow to model positive and negative relationships. We analyze existing extensions of spectral clustering to signed networks. It turns out that existing approaches do not recover the ground truth clustering in several situations where ...
Hein, Matthias +2 more
core
Further Improved Weighted Arithmetic-Geometric Operator Mean Inequalities
Mathematics, 2019 The main purpose of this paper is to present some weighted arithmetic-geometric operator mean inequalities. These inequalities are refinements and generalizations of the corresponding results.
Jianming Xue, Xingkai Hu
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Mean annual geometric mean at Manitoba beaches, 2007–2021.
Mean annual geometric mean at Manitoba beaches, 2007–2021.
Binyam N. Desta (18309278) +4 more
core +2 more sources
Север и рынок: формирование экономического порядка, 2023 The relevance of developing the construction sector in Russia stems from the imperative to 1) enhance productivity, 2) reduce costs and improve quality and safety, and 3) address future challenges such as climate change and economic diversification. This
Ekaterina K. Tereshko +2 more
doaj +1 more source