Results 61 to 70 of about 1,117,649 (332)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Assessing Standard Error Estimation Approaches for Robust Mean-Geometric Mean Linking

open access: yesAppliedMath
Robust mean-geometric mean (MGM) linking methods enable reliable group comparisons in item response theory models under fixed and sparse differential item functioning.
Alexander Robitzsch
doaj   +1 more source

The geometric mean of two matrices from a computational viewpoint [PDF]

open access: yes, 2011
The geometric mean of two matrices is considered and analyzed from a computational viewpoint. Some useful theoretical properties are derived and an analysis of the conditioning is performed.
Iannazzo, Bruno
core  

The Geometrization of Meaning

open access: yes, 2021
One of the greatest problems in philosophy is that of meaning. The turning point in thinking on meaning was Tarski's definition of truth, and the rapid development of logical semantics and model theory was a consequence of this achievement. Perhaps less well-known among classical logicians and philosophers is that it is category theory that provides ...
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Optimal bounds for Seiffert-like elliptic integral mean by harmonic, geometric, and arithmetic means

open access: yesJournal of Inequalities and Applications, 2022
In this article, we present the optimal bounds for a special elliptic integral mean in terms of the harmonic combinations of harmonic, geometric, and arithmetic means.
Fan Zhang, Weimao Qian, Hui Zuo Xu
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Two-Stage Classification with SIS Using a New Filter Ranking Method in High Throughput Data

open access: yesMathematics, 2019
Over the last decade, high dimensional data have been popularly paid attention to in bioinformatics. These data increase the likelihood of detecting the most promising novel information.
Sangjin Kim, Jong-Min Kim
doaj   +1 more source

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