Results 51 to 60 of about 317,626 (258)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Optimal bounds for Seiffert-like elliptic integral mean by harmonic, geometric, and arithmetic means

open access: yesJournal of Inequalities and Applications, 2022
In this article, we present the optimal bounds for a special elliptic integral mean in terms of the harmonic combinations of harmonic, geometric, and arithmetic means.
Fan Zhang, Weimao Qian, Hui Zuo Xu
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Two-Stage Classification with SIS Using a New Filter Ranking Method in High Throughput Data

open access: yesMathematics, 2019
Over the last decade, high dimensional data have been popularly paid attention to in bioinformatics. These data increase the likelihood of detecting the most promising novel information.
Sangjin Kim, Jong-Min Kim
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Geometric mean and standard geometric deviation of groups.

open access: yes, 2014
Data are presented as geometric mean (GM) and geometric standard deviation (GSD).Geometric mean and standard geometric deviation of groups.
Flávia Valladão Thiesen (680124)   +4 more
core   +1 more source

The geometric mean algorithm [PDF]

open access: yes, 2012
Bisection (of a real interval) is a well known algorithm to compute eigenvalues of symmetric matrices. Given an initial interval [a,b], convergence to an eigenvalue which has size much smaller than a or b may be made considerably faster if one replaces ...
Ralha, Rui
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Some weighted operator geometric mean inequalities

open access: yesپژوهش‌های ریاضی, 2017
In this paper, using the extended Holder- -McCarthy inequality, several inequalities involving the α-weighted geometric mean ...
Alemeh Sheikhhosseini   +2 more
doaj  

Statistical measures of the central tendency for H+ activity and pH

open access: yesSoil Science Annual, 2017
Despite the numerous papers on the statistical analyses of pH, there is no explicit opinion on the use of arithmetic mean as a measure of the central tendency for pH and H+ activity.
Kuna-Broniowska Izabela, Smal Halina
doaj   +1 more source

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