Results 41 to 50 of about 479,657 (292)

Inflationary back-reaction effects from Relativistic Quantum Geometry

open access: yes, 2015
We study the dynamics of scalar metric fluctuations in a non-perturbative variational formalism recently introduced, by which the dynamics of an geometrical scalar field $\theta$, describes the quantum geometrical effects on a Weylian-like manifold with ...
Bellini, Mauricio
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Geometrical phases and quantum numbers of solitons in nonlinear sigma-models [PDF]

open access: yes, 2001
Solitons of a nonlinear field interacting with fermions often acquire a fermionic number or an electric charge if fermions carry a charge. We show how the same mechanism (chiral anomaly) gives solitons statistical and rotational properties of fermions ...
Abanov, A. G., Wiegmann, P. B.
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Information Geometrical Characterization of Quantum Statistical Models in Quantum Estimation Theory

open access: yesEntropy, 2019
In this paper, we classify quantum statistical models based on their information geometric properties and the estimation error bound, known as the Holevo bound, into four different classes: classical, quasi-classical, D-invariant, and asymptotically ...
Jun Suzuki
doaj   +1 more source

Towards realistic models of quark masses with geometrical CP violation

open access: yes, 2014
We present a model for quark masses and mixing, featuring geometrical CP violation through a \Delta(27) triplet. By employing a single U(1)_F or Z_N symmetry in addition to \Delta(27), we forbid all terms in the scalar potential that would spoil the ...
Pidt, Daniel, Varzielas, Ivo de Medeiros
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Comparison of Geometrical Lung Models to Calculate Tidal Volumes during Spontaneous Breathing

open access: yesCurrent Directions in Biomedical Engineering, 2021
Demographic changes, increasing air pollution and the ongoing Covid-19 pandemic, causing virus-induced respiratory failures, monitoring of respiratory parameters is the focus of international interest.
Beck Simon   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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