Results 41 to 50 of about 6,856,252 (290)
Eye and Vision, 2020 Background Biomechanics introduces numerous technologies to support clinical practice in ophthalmology, with the goal of improving surgical outcomes and to develop new advanced technologies with minimum impact on clinical training.
Anna Pandolfi
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Soft Tissue Structure Modelling for Use in Orthopaedic Applications and Musculoskeletal Biomechanics
EURASIP Journal on Advances in Signal Processing, 2010 We present our methodology for the three-dimensional anatomical and geometrical description of soft tissues, relevant for orthopaedic surgical applications and musculoskeletal biomechanics.
van Hoof T +3 more
doaj +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Comparison of Geometrical Lung Models to Calculate Tidal Volumes during Spontaneous Breathing
Current Directions in Biomedical Engineering, 2021 Demographic changes, increasing air pollution and the ongoing Covid-19 pandemic, causing virus-induced respiratory failures, monitoring of respiratory parameters is the focus of international interest.
Beck Simon +2 more
doaj +1 more source
Categorical data modelling for Cylindricity Consistent with Geometrical Product Specifications Standard System [PDF]
, 2010 Geometrical Product Specifications and Verification (Abbreviated as GPS) is an international standard system regarding standardization of dimensional, tolerancing, surface texture and related metrological principles and practices in the charge of ...
Paul Scott +10 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source