Results 41 to 50 of about 63,827 (265)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
AUTEX Research Journal, 2020 This work deals with prediction of the quantities of sewing threads required to sew a garment using cover stitches for the different classes of 600 (602, 605 and 607 cover stitches) by performing a rapid and precise methods (Geometrical and statistical).
Sarah Malek +2 more
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Physical models from noncommutative causality
EPJ Web of Conferences, 2018 We introduced few years ago a new notion of causality for noncommutative spacetimes directly related to the Dirac operator and the concept of Lorentzian spectral triple.
Franco Nicolas
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Aerospace, 2023 Combustion instability constitutes the primary loss source of combustion chambers, gas turbines, and aero engines, and it affects combustion performance or results in a sudden local oscillation.
Nan Meng, Feng Li
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Interval methods in geometric modeling
Proceedings Geometric Modeling and Processing 2000. Theory and Applications, 2000 This paper is about using interval computations in location, simplification, and root-finding for multivariate implicit functions that are used as shape primitives in a set-theoretic (that is, a CSG) geometric modeller. Three problems are discussed, and solutions to them presented: the location and simplification of the surfaces of semialgebraic sets ...
Bowyer, A +4 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source