Results 51 to 60 of about 63,827 (265)

CFD-model of the mass transfer in the vertical settler

Nauka ta progres transportu, 2013
Purpose. Nowadays the mathematical models of the secondary settlers are intensively developed. As a rule the engineers use the 0-D models or 1-D models to design settlers.
E. K. Nagornaya
doaj  

Phenomenological modeling of geometric metasurfaces

Optics Express, 2016
Metasurfaces, with their superior capability in manipulating the optical wavefront at the subwavelength scale and low manufacturing complexity, have shown great potential for planar photonics and novel optical devices. However, vector field simulation of metasurfaces is so far limited to periodic-structured metasurfaces containing a small number of ...
Ye, Weimin, Guo, Qinghua, Xiang, Yuangjiang, Fan, Dianyuan, Zhang, Shuang   +4 more
openaire   +4 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Geometrical four-point functions in the two-dimensional critical Q-state Potts model: connections with the RSOS models

Journal of High Energy Physics, 2020
The “bootstrap determination” of the geometrical correlation functions in the two-dimensional Potts model proposed in a paper by Picco et al. [1] was later shown in [2] to be incorrect, the actual spectrum of the model being considerably more complex ...
Yifei He, Linnea Grans-Samuelsson, Jesper Lykke Jacobsen, Hubert Saleur   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Numerical Simulations of the Transport of Newtonian and Non-newtonian Fluids via Peristaltic Motion

Applied Rheology, 2018
Two geometrical models are developed to simulate fluid transport via peristaltic motion in tubes of uniform or linearly decreasing radius: A 2-D axisymmetric tubular model and a 2-D axisymmetric conical model.
Alokaily Samer, Feigl Kathleen, Tanner Franz X., Windhab Erich J.   +3 more
doaj   +1 more source

Corner arches in spanish renaissance treatises and manuscripts

EGA, 2015
Corner arches are a peculiar architectural type of the Spanish Renaissance. This article presents a transversal vision of the strategies put forward in treatises and manuscripts in order to tackle the problem of opening arches at the intersection of two ...
Ricardo García Baño, José Calvo López   +1 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source