Results 31 to 40 of about 503,328 (248)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Optimization of voids in concrete ceilings: A geometrical approach [PDF]
FME Transactions, 2019 The task to reduce the material consumption in the building industry is urgent. Conserving concrete saves nature and money. To reduce the consumption of concrete in buildings we design hollow bodies in ceiling structures.
Noack Kevin +2 more
doaj
A low-energy limit of Yang-Mills theory on de Sitter space
Journal of High Energy Physics, 2021 We consider Yang-Mills theory with a compact structure group G on four-dimensional de Sitter space dS4. Using conformal invariance, we transform the theory from dS4 to the finite cylinder I $$ \mathcal{I} $$ × S 3, where I $$ \mathcal{I} $$ = (−π/2, π/2)
Josh Cork +3 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Weyl metrics and Wiener-Hopf factorization
Journal of High Energy Physics, 2020 We consider the Riemann-Hilbert factorization approach to the construction of Weyl metrics in four space-time dimensions. We present, for the first time, a rigorous proof of the remarkable fact that the canonical Wiener-Hopf factorization of a matrix ...
P. Aniceto +3 more
doaj +1 more source
Smart Topology Optimization Using Adaptive Neighborhood Simulated Annealing
Applied Sciences, 2021 Topology optimization (TO) of engineering products is an important design task to maximize performance and efficiency, which can be divided into two main categories of gradient-based and non-gradient-based methods.
Hossein R. Najafabadi +5 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Automated detection, labelling and radiological grading of clinical spinal MRIs
Scientific ReportsSpinal magnetic resonance (MR) scans are a vital tool for diagnosing the cause of back pain for many diseases and conditions. However, interpreting clinically useful information from these scans can be challenging, time-consuming and hard to reproduce ...
Rhydian Windsor +3 more
doaj +1 more source