Results 41 to 50 of about 503,328 (248)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Safety of Learners and Teachers in School: A Criminological Analysis

International Journal of Social Sciences & Educational Studies
Recent study revealed that safety of learners and teachers continues to be a matter of major concern in the South African schools. Learners and teachers are no longer safe due to an increased level of violence in the schools.
Puseletso. A Dewee, Khethiwe Madima, Thifhulwifhelwi C. Tshidada   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Tight Wavelet Frame Decomposition and Its Application in Image Processing

Journal of Mathematical and Fundamental Sciences, 2013
This paper is devoted to the formulation of a decomposition algorithm using tight wavelet frames, in a multivariate setting. We provide an alternative method for decomposing multivariate functions without accomplishing any tensor product. Furthermore, we
Mahmud Yunus, Hendra Gunawan
doaj   +1 more source

Geometry over composition algebras: Projective geometry

Journal of Algebra, 2006
The purpose of this article is to introduce projective geometry over composition algebras : the equivalent of projective spaces and Grassmannians over them are defined. It will follow from this definition that the projective spaces are in correspondance with Jordan algebras and that the points of a projective space correspond to rank one matrices in ...
openaire   +3 more sources

W-geometries [PDF]

Physics Letters B, 1992
It is shown that, classically, the W-algebras are directly related to the extrinsic geometry of the embedding of two-dimensional manifolds with chiral parametrisation (W-surfaces) into higher dimensional K hler manifolds. We study the local and the global geometries of such embeddings, and connect them to Toda equations.
Gervais, Jean-Loup, Matsuo, Yutaka
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Observations on holographic aspects of four-dimensional asymptotically flat N $$ \mathcal{N} $$ = 2 black holes

Journal of High Energy Physics, 2022
In this note, we explore holographic attributes of four-dimensional near-extremal Reissner-Nordstrom black hole solutions in ungauged N $$ \mathcal{N} $$ = 2 supergravity theories at the two-derivative level by recasting them as a specific first-order ...
Pedro Aniceto, Gabriel Lopes Cardoso, Suresh Nampuri   +2 more
doaj   +1 more source