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Science Is a Lot of Fun: How Professor Jes Olesen Made Discoveries in Migraine [PDF]
Eur J NeurolThe human provocation model, cortical spreading depression during the aura and the identification of CGRP all came from one investigator following the same method for 60 years. Marking the 85th birthday of Professor Jes Olesen, Honorary Member of the EAN and founder of the European Journal of Neurology, this interview describes how each discovery was ...
Lebedeva E.
europepmc +2 more sources
, 2022 Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms, including aura. The aetiology is multifactorial with rare monogenic variants.
Goadsby, P.J. +26 more
core +1 more source
Brain and Behavior, Volume 16, Issue 7, July 2026.ABSTRACT Background The Leeds Dependence Questionnaire (LDQ) is a validated tool for assessing psychological dependence across various substances and has been adapted for use in headache patients. No study has yet explored the effects of preventive anti‐CGRP treatments like atogepant on psychological dependence related to acute migraine medications ...
Luigi Francesco Iannone +6 more
wiley +1 more source
Frontiers in NeurologyBackgroundEpisodic migraine is a prevalent and disabling neurological disorder with a significant impact on quality of life and productivity. Preventive treatment aims to reduce the frequency, intensity, and disability associated with migraine attacks ...
María-Karina Vélez-Jiménez +15 more
doaj +1 more source
, 2019 Aim: The aim of present study is to investigate the binding characteristics of non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists (i.e., gepants) in the brain membranes of rat, pig and human.
Edvinsson, Lars +9 more
core +1 more source
Brain and Behavior, Volume 16, Issue 7, July 2026.ABSTRACT Objective This network meta‐analysis (NMA) aimed to compare and rank the efficacy and acceptability of different noninvasive brain stimulation (NIBS) techniques for migraine treatment in adults. Method We systematically searched PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov through October 13, 2025, for randomized ...
Wen‐Ting Sun +7 more
wiley +1 more source
, 2017 AIM: The neuropeptide calcitonin gene-related peptide (CGRP) is found in afferent sensory nerve fibers innervating the resistance arteries and plays a pivotal role in a number of neurovascular diseases such as migraine and subarachnoid bleedings.
Pickering, Darryl S +15 more
core +1 more source
Novel synthetic treatment options for migraine
, 2020 Introduction: Migraine is one of the most common neurological disorders. Nowadays, the 5-HT1B/1D receptor agonists, namely triptans, are considered as the standard of care for migraine acute treatment. However, triptans have limitations in some patients,
Martelletti P. +3 more
core +1 more source
New therapeutic options in migraine treatment
Journal of Education, Health and SportIntroduction and purpose Migraine is a common disease mostly affecting women. It has a huge influence on patients’ life strongly decreasing its quality by cause of repetitive headache episodes and often comes with unpleasant and burdensome symptoms ...
Aleksandra Kłos +9 more
doaj +1 more source
Frontiers in NeurologyMigraine, a prevalent neurological disorder, affects approximately 14.1% of the global population and disproportionately impacts females. This debilitating condition significantly compromises quality of life, productivity, and incurs high healthcare ...
A. Özge +6 more
doaj +1 more source