Results 101 to 110 of about 224,238 (268)
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Advanced Science, EarlyView.A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin +17 more
wiley +1 more source
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
AGING MEDICINE, EarlyView.Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang +3 more
wiley +1 more source
AGING MEDICINE, EarlyView.This consensus describes the protective effect and safety of influenza and pneumococcal vaccines, and vaccination recommendations, aiming to promote the vaccination rate, better play the role of vaccines in preventing influenza and pneumococcal diseases, and reduce the occurrence of respiratory infections and related serious complications in elderly ...
Lijing Wang +31 more
wiley +1 more source
AGING MEDICINE, EarlyView.Evaluation of geriatric guidelines and consensus in 2023 using the STAR tool shows improved scientificity and transparency compared to 2022, though protocol development, funding, and clinical issues need refinement. Collaborative efforts among developers, journals, and experts are key to further elevating quality. ABSTRACT Objectives This study aims to
Daiping Li +12 more
wiley +1 more source
Beneficial Body Mass Index for Age‐Related Kidney Function in Males and Females
AGING MEDICINE, EarlyView.The impact of BMI on age‐related kidney function decline is highly sex‐ and age‐dependent. Normal BMI (18.5–25 kg/m2) is associated with better age‐related kidney function in all‐aged males and females older than 45 years. ABSTRACT Objectives Kidney function declines with aging, leading to a high prevalence of age‐related disease.
Lu Wei +7 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya +2 more
wiley +1 more source
Preparing for an ageing Tanzania: cross-sectional study assessing the undergraduate health students' knowledge, attitudes and barriers to geriatric nutrition assessment. [PDF]
BMJ OpenRashid RM, Peter DE, Millanzi WC.
europepmc +1 more source