Results 111 to 120 of about 323,912 (312)

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

Determination of geriatric patients' drug profile and identify their pharmaceutical care requirements by determining potential risk factors

open access: yes, 2011
Purpose: The aim of this study is to evaluate the geriatric drug usage, assess the appropriateness of their drug treatment and identify their pharmaceutical care requirements.
OKUYAN, BETÜL
core   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu   +14 more
wiley   +1 more source

Deep Learning for AD Risk Screening and Progression Prediction

open access: yesAdvanced Science, EarlyView.
A pretrained MRI‐based deep learning model generalizes from Western cohorts to an independent Chinese cohort, detects Alzheimer's disease with high sensitivity, and identifies elevated AD risk years before diagnosis. Its risk scores align with cognition and plasma biomarkers, and individualized brain risk maps uncover clinically distinct subtypes ...
Bin Lu   +12 more
wiley   +1 more source

Study of Morbidity Pattern, Activities of Daily Living and Health Seeking Behavior among Rural Elderly in Jammu District

open access: yesNational Journal of Community Medicine, 2018
Introduction: Elderly are the fastest growing segment of popula- tion due to demographic transition. This study was conducted to assess the morbidity pattern, health seeking behaviour and func- tional status of geriatric age group using Katz index ...
Kiran Bala   +3 more
doaj  

Globalization of Korean Geriatric Psychiatry [PDF]

open access: yes, 2004
The Korean Association for Geriatric Psychiatry was founded in 1994. “2004 IPA Asia Pacific Regional Meeting” was held successfully on 8-11 September in Seoul, Korea.
오병훈
core  

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

open access: yesAdvanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song   +5 more
wiley   +1 more source

Adherence to Anti-Hypertensive Drugs: A Clinic Based Study among Geriatric Hypertensive Patients in Rural, India

open access: yesNational Journal of Community Medicine, 2018
Background: Hypertension is a common chronic health condition, more among the elderly and is the most important risk factor for all subtypes of vascular disease and death.
Sanjaya Kumar Sahoo   +2 more
doaj  

European training requirements in geriatric medicine 2025 : driving competency-based education and harmonisation across Europe

open access: yes
Purpose: To describe the process, content, and significance of the 2025 revision of the European Training Requirements (ETR) for the Specialty of Geriatric Medicine, developed under the auspices of the European Union of Medical Specialists Geriatric ...
Nuotio, Maria S.   +37 more
core   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu   +5 more
wiley   +1 more source

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