Results 111 to 120 of about 298,884 (351)

The Case for Mobility Assessment in Hospitalized Older Adults: American Geriatrics Society White Paper Executive Summary

Journal of The American Geriatrics Society, 2018
Mobility can be defined as the ability to move or be moved freely and easily. In older adults, mobility impairments are common and associated with risk for additional loss of function.
H. Wald, Ravishankar Ramaswamy, M. Perskin, Lloyd Roberts, Michael Bogaisky, Winnie Suen, Anna Mikhailovich   +6 more
semanticscholar   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer’s disease: Report of an autopsy case

Vascular Health and Risk Management, 2008
Cédric Annweiler1, Marc Paccalin2, Gilles Berrut3, Caroline Hommet4, Christian Lavigne1, Jean-Paul Saint-André5, Olivier Beauchet11Department of Geriatrics and Internal Medicine, Angers University Hospital, France; 2Department of Geriatrics,
Cédric Annweiler, Marc Paccalin, Gilles Berrut, Caroline Hommet, Christian Lavigne, et al   +5 more
doaj  

The choice of self-rated health measures matter when predicting mortality: evidence from 10 years follow-up of the Australian longitudinal study of ageing [PDF]

, 2016
BACKGROUND Self-rated health (SRH) measures with different wording and reference points are often used as equivalent health indicators in public health surveys estimating health outcomes such as healthy life expectancies and mortality for older adults ...
Anstey, Kaarin, Luszcz, Mary A, Sargent-Cox, Kerry A   +2 more
core   +1 more source

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset

Advanced Science, EarlyView.
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng, Hua Wang, Li Zhang, Shiping Li, Yuan Yuan, Mengting Tian, Yi Qu, Junjie Ying, Meicen Zhou, Yong Hu, Jinglan Huang, Rong Zou, Fengyan Zhao, Xiaojuan Su, Qian Liu, Yan He, Jinxing Feng, Weimin Huang, Ying Luo, Zhemin Zhou, Wei Shen, Dezhi Mu, Shaopu Wang   +22 more
wiley   +1 more source

Safe Driving for the Mature Adult: Selected Issues [PDF]

, 2017
Educational Objectives 1. Examine issues related to aging and driving assessment. 2. Review Virginia’s Mature Drivers Study. 3. Discuss the levels of care for prevention of driving disability and resources available at each level. 4.
Parsio, Rebecca
core   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Prediction of Pharmacokinetics for CYP3A4-Metabolized Drugs in Pediatrics and Geriatrics Using Dynamic Age-Dependent Physiologically Based Pharmacokinetic Models

Pharmaceutics
Background/Objectives: The use of medicines in pediatrics and geriatrics is widespread. However, information on pharmacokinetics of therapeutic drugs mainly comes from healthy adults, and the pharmacokinetic parameters of therapeutic drugs in other age ...
Jing Han, Zexin Zhang, Xiaodong Liu, Hanyu Yang, Li Liu   +4 more
doaj   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source