Results 111 to 120 of about 154,606 (294)

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Enhancing the Predictive Utility of MHR for Senile Osteoporosis: Unaddressed Considerations and Future Directions [Response to Letter]

Clinical Interventions in Aging
Dang Li,1,2 Nan Lin1 1Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Clinical Research Center for Senile Vascular Aging and Brain Aging, Fujian Medical University Union Hospital, Fuzhou, Fujian ...
Lin N, Li D, Lin S, Ke Y, Lu J, Wu Y, Huang T, Hong H   +7 more
doaj  

Analysis of foodborne disease surveillance of geriatrics from 2018 to 2022 in China’s Mainland

Zhongguo shipin weisheng zazhi
ObjectiveTo provide scientific basis for the prevention and control of foodborne diseases among the geriatrics in China’s Mainland， the epidemiological characteristics of foodborne diseases was understood.MethodsInformation on acute gastroenteritis cases
FAN Penghui, ZHANG Ronghua, HUO Xiang, LIN Li, JIANG Yuyan, MA Xiaochen, LIU Hong, LIU Zhitao, CHU Zunhua, LIANG Jinjun, HU Qingwen, LIU Jikai, HAN Haihong, LI Weiwei   +13 more
doaj   +1 more source

ESPEN guideline on clinical nutrition and hydration in geriatrics.

Clinical Nutrition, 2019
D. Volkert, A. Beck, T. Cederholm, A. Cruz-Jentoft, S. Goisser, L. Hooper, E. Kiesswetter, M. Maggio, A. Raynaud-Simon, C. Sieber, L. Sobotka, D. V. van Asselt, R. Wirth, S. Bischoff   +13 more
semanticscholar   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Bacterial profile and antimicrobial susceptibility pattern of community and hospital-acquired urinary tract infections among UTI suspected geriatrics in Gondar town, Northwest Ethiopia.

PLoS ONE
BackgroundBacterial urinary tract infection (UTI) is the second most frequent infection next to respiratory tract infection within the geriatric population both in the community and hospital settings.
Getachew Bitew Alebachew, Mulat Dagnew, Aklilu Ambachew, Belay Tessema   +3 more
doaj   +1 more source

Carbon‐Coated Probiotics Restore Intestinal Homeostasis to Promote Damage Repair in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Carbon‐coated Lactobacillus rhamnosus GG (C dots@LGG) enhances the antioxidant effects of LGG and safeguards the probiotics to target the inflamed colon. This reduces inflammation and oxidative damage, repairs the intestinal barrier, regulates the microbiota, and alleviates colitis.
Xue Chen, Haiyan Guo, Yuhan Li, Qiaowen Lin, Hua Liu, Liwen Hong, Lei Wang, Jie Zhong, Dalong Ni, Zhengting Wang   +9 more
wiley   +1 more source

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

Advanced Science, EarlyView.
This work found that early‐stage insulin sensitization but late‐stage insulin resistance in prenatal caffeine exposure (PCE)‐ induced intrauterine growth restriction (IUGR) offspring may be related to the hepatic AGEs accumulation via intrauterine GR/miR‐1224 programming by glucocorticoids.
Yongguo Dai, Xiaoling Guo, Pengxia Yu, Dingmei Zhang, Hao Kou, Hui Wang   +5 more
wiley   +1 more source

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Association between chronic obstructive pulmonary disease and activity of daily living among oldest-old in China: based on Chinese Longitudinal Health Longevity Survey

International Journal of COPD, 2019
Miao Liu,1,* Yanhong Yue,2,* Yao He11Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, State Key Laboratory of Kidney Diseases, Second Medical Center of Chinese PLA General
Liu M, Yue Y, He Y
doaj