Results 131 to 140 of about 285,790 (386)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

open access: yesAdvanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma   +9 more
wiley   +1 more source

The geriatric 5Ms, artificial intelligence, and Hannah Arendt’s critique: ethical reflections within contemporary gerontology [PDF]

open access: yesGeriatrics, Gerontology and Aging
The intersection of geriatrics, artificial intelligence (AI), and ethics presents a growing challenge in the field of aging medicine. The Geriatric 5Ms framework — Mind, Mobility, Medications, Multicomplexity, and Matters Most — guides current clinical ...
Virgílio Garcia Moreira   +2 more
doaj   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen   +9 more
wiley   +1 more source

Comparing Iranian and Duke University\'s Master of Nursing Education Programs in Geriatrics: A Comparative Study [PDF]

open access: yesPizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī
Introduction: To identify the strengths and weaknesses of the curriculum and improve the quality of education in the Master of Nursing in Geriatrics, this study aimed to compare the educational program of the Master of Nursing in Geriatrics at Golestan ...
Hamideh Mancheri   +3 more
doaj  

Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia

open access: yesAdvanced Science, EarlyView.
The work constructs a glucose‐triggered gel for diabetic abscess treatment. The results demonstrate that the gel catalyzes glucose into oxygen, alleviates the hypoxia, and ensures sufficient ROS generation to combat pathogenic bacteria. Simultaneously, borneol within the gel can enhance the antibacterial activity of ROS and alleviate pain in patients ...
Bin Huang   +12 more
wiley   +1 more source

An Initial Study on the Ethical and Moral Standards of Geriatrics Clinical Instructors Construction

open access: yesGuoji laonian yixue zazhi
Objective With the accelerating aging of the global population, the geriatrics has garnered significant attention in recent years. Geriatrics clinical specialty medical students represent a crucial talent pool for this field.
Xu ying, Tao Xinyu, Chen Sen, Qu Chen
doaj   +1 more source

Healthy Aging: American Geriatrics Society White Paper Executive Summary

open access: yesJournal of The American Geriatrics Society, 2018
In July 2015, the Journal of the American Geriatrics Society published a manuscript titled, “Failing to Focus on Healthy Aging: A Frailty of Our Discipline?” In response, the American Geriatrics Society (AGS) Clinical Practice and Models of Care ...
S. M. Friedman   +8 more
semanticscholar   +1 more source

INTEGRATING GERIATRICS INTO THE ACUTE HOSPITAL SETTING: NOW OR IN THE FUTURE? [PDF]

open access: yes
The demographic ageing of the population and its impact on social systems, economies or labor markets have often been analyzed and discussed in Germany. The German health care system is expected to face great challenges due to the “double-ageing” of the ...
Fastenmeier Heribert, Leuca Mirela
core  

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