Results 131 to 140 of about 298,884 (351)

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Education and training in geriatrics: guiding the generational change of health professionals

Geriatric Care
The increased volume of the aged population, the complexity of patients, and the updates in the legislative aspects linked to older people constitute various challenges for geriatrics.
Liliana Mazza, Lorenzo Palleschi
doaj   +1 more source

Toxicity Profiles of Commonly Used Anti-Inflammatory Drugs in Geriatrics

, 2020
Talal M. Ziad Alhouzani, Mohammad Saleem, Sitaram Khadka, Saleh Musaed Mohammed Al-Subari, Dhan Bahadur Shrestha, Imamah Anwar Butt   +5 more
openalex   +2 more sources

Increasing Telehealth Visits for Older Veterans Associated with Decreased No-Show Rate in a Geriatrics Consultation Clinic [PDF]

, 2022
Andrea Wershof Schwartz, Jane A. Driver, Lisa M. Pollara, John Roefaro, Mary Harrington, Michael E. Charness, Lara M. Skarf   +6 more
openalex   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

The clinical method in geriatrics

Medisur, 2010
Population aging and the distinctive characteristics of elderly require a particular implementation of the clinical method. Taking into account the special health problems of elderly, the geriatric evaluation is the cornerstone for the medical attention ...
Ángel Julio Romero Cabrera, Alfredo Darío Espinosa Brito   +1 more
doaj   +2 more sources

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

National Database of Geriatrics

Clinical Epidemiology, 2016
Pia Nimann Kannegaard,1 Kirsten L Vinding,2 Helle Hare-Bruun3 1Copenhagen University Hospital, Faculty of Health and Medical Science, Herlev-Gentofte, Geriatric Medical Unit, Capital Region of Denmark, Hellerup, 2Lillebaelt Hospital, Department of ...
Kannegaard PN, Vinding KL, Hare-Bruun H
doaj  

Interventions for fall prevention in community-dwelling older persons [PDF]

, 2019
Falls in individuals over the age of 65 is a pervasive problem resulting in significant health and economic burden in our country. Thus, effective fall prevention strategies are an important public health measure, especially in an age group that is ...
Roy, Gregory S
core   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source