Results 11 to 20 of about 238,883 (265)
Frontiers in Cell and Developmental Biology, 2018 Germ cell research in vertebrates has traditionally been challenging, but recent breakthroughs have overcome technical difficulties, demonstrating and expanding the power of the zebrafish experimental system for their analysis in vivo. Exploiting the transparency of the zebrafish embryo, germ cell migration was the first topic that moved the germ cells
Roland Dosch, Roland Dosch
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Cell, 2008 Germ cells are the only cell type capable of generating an entirely new organism. In order to execute germline-specific functions and to retain the capacity for totipotency, germ cells repress somatic differentiation, interact with a specialized microenvironment, and use germline-specific networks of RNA regulation.
Cinalli, Ryan M. +2 more
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Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. [PDF]
PLoS ONE, 2014 In Drosophila melanogaster, primordial germ cells are specified at the posterior pole of the very early embryo. This process is regulated by the posterior localized germ plasm that contains a large number of RNAs of maternal origin.
Ferenc Jankovics +6 more
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Germ cell determination and the developmental origin of germ cell tumors [PDF]
Development, 2021 ABSTRACT In each generation, the germline is tasked with producing somatic lineages that form the body, and segregating a population of cells for gametogenesis. During animal development, when do cells of the germline irreversibly commit to producing gametes?
Peter K. Nicholls, David C. Page
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Tracing the cellular basis of islet specification in mouse pancreas
Nature Communications, 2020 The cellular basis of islet morphogenesis and fate allocation remain unclear. Here, the authors use a R26-CreER-R26R-Confetti mouse line to follow quantitatively the clonal dynamics of islet formation showing how, during the secondary transition, islet ...
Magdalena K. Sznurkowska +7 more
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Current Opinion in Genetics & Development, 1999 Recently, cell signaling has been shown to be required for the formation of germ cells in the mouse embryo, direct observation of germ cell migration in living mouse embryos has been achieved, novel genes that control germ-cell migration have been identified in Drosophila, and the roles of many components of germ plasm in several species have become ...
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Cell cycle regulation for meiosis in mammalian germ cells
The Journal of Reproduction and Development, 2023 In mouse fetal gonads, germ cell development is accompanied by changes in cell cycle mode in response to external signals and intrinsic mechanisms of cells.
Ryuki SHIMADA, Kei-ichiro ISHIGURO
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Role of β-catenin in post-meiotic male germ cell differentiation. [PDF]
PLoS ONE, 2011 Though roles of β-catenin signaling during testis development have been well established, relatively little is known about its role in postnatal testicular physiology.
Yao-Fu Chang +4 more
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, 2012 The germline of Caenorhabditis elegans derives from a single founder cell, the germline blastomere P(4). P(4) is the product of four asymmetric cleavages that divide the zygote into distinct somatic and germline (P) lineages. P(4) inherits a specialized cytoplasm ("germ plasm") containing maternally encoded proteins and RNAs.
Jennifer T, Wang, Geraldine, Seydoux
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Of Stem Cells and Germ Cells [PDF]
Reproduction in Domestic Animals, 2011 ContentsStem cells have an intrinsic capacity to self‐renew and can differentiate to at least one specialized cell type. Different types of stem cells exist that can be culturedin vitro. The identity of the stem cells is marked by their origin and differentiation potential.
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