Results 21 to 30 of about 238,883 (265)

SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

Stem Cell Reports, 2017
In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRα1)-positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent
Moe Tokue, Kanako Ikami, Seiya Mizuno, Chiyo Takagi, Asuka Miyagi, Ritsuko Takada, Chiyo Noda, Yu Kitadate, Kenshiro Hara, Hiroko Mizuguchi, Takuya Sato, Makoto Mark Taketo, Fumihiro Sugiyama, Takehiko Ogawa, Satoru Kobayashi, Naoto Ueno, Satoru Takahashi, Shinji Takada, Shosei Yoshida   +18 more
doaj   +1 more source

Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. [PDF]

PLoS ONE, 2014
The piRNA pathway plays an important role in maintaining genome stability in the germ line by silencing transposable elements (TEs) from fly to mammals.
Xing Ma, Su Wang, Trieu Do, Xiaoqing Song, Mayu Inaba, Yoshiya Nishimoto, Lu-ping Liu, Yuan Gao, Ying Mao, Hui Li, William McDowell, Jungeun Park, Kate Malanowski, Allison Peak, Anoja Perera, Hua Li, Karin Gaudenz, Jeff Haug, Yukiko Yamashita, Haifan Lin, Jian-quan Ni, Ting Xie   +21 more
doaj   +1 more source

Mitotic arrest in teratoma susceptible fetal male germ cells. [PDF]

PLoS ONE, 2011
Formation of germ cell derived teratomas occurs in mice of the 129/SvJ strain, but not in C57Bl/6 inbred or CD1 outbred mice. Despite this, there have been few comparative studies aimed at determining the similarities and differences between teratoma ...
Patrick S Western, Rachael A Ralli, Stephanie I Wakeling, Camden Lo, Jocelyn A van den Bergen, Denise C Miles, Andrew H Sinclair   +6 more
doaj   +1 more source

A pilgrim's progress: Seeking meaning in primordial germ cell migration

Stem Cell Research, 2017
Comparative studies of primordial germ cell (PGC) development across organisms in many phyla reveal surprising diversity in the route of migration, timing and underlying molecular mechanisms, suggesting that the process of migration itself is conserved ...
Andrea V. Cantú, Diana J. Laird
doaj   +1 more source

Dissecting chicken germ cell dynamics by combining a germ cell tracing transgenic chicken model with single-cell RNA sequencing

Computational and Structural Biotechnology Journal, 2022
Avian germ cells can be distinguished by certain characteristics during development. On the basis of these characteristics, germ cells can be used for germline transmission.
Deivendran Rengaraj, Dong Gon Cha, Hong Jo Lee, Kyung Youn Lee, Yoon Ha Choi, Kyung Min Jung, Young Min Kim, Hee Jung Choi, Hyeon Jeong Choi, Eunhui Yoo, Seung Je Woo, Jin Se Park, Kyung Je Park, Jong Kyoung Kim, Jae Yong Han   +14 more
doaj   +1 more source

Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. [PDF]

PLoS ONE, 2016
The mechanisms underlying human germ cell development are largely unknown, partly due to the scarcity of primordial germ cells and the inaccessibility of the human germline to genetic analysis.
Sarita Panula, Ahmed Reda, Jan-Bernd Stukenborg, Cyril Ramathal, Meena Sukhwani, Halima Albalushi, Daniel Edsgärd, Michiko Nakamura, Olle Söder, Kyle E Orwig, Shinya Yamanaka, Renee A Reijo Pera, Outi Hovatta   +12 more
doaj   +1 more source

Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report

Acta Clinica Croatica, 2023
Intracranial germ cell tumors are rare brain tumors that are distinguished based on their histology and selected tumor markers. Non-germinomatous germ cell tumors are a diverse group of such tumors having the poorest prognosis.
Nikolina Sesar, Bruno Splavski, Marija Gamulin, Krešimir Rotim   +3 more
doaj   +1 more source

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. [PDF]

PLoS ONE, 2013
Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either infertility or malignant aberration.
Jana Schemmer, Marcos J Araúzo-Bravo, Natalie Haas, Sabine Schäfer, Susanne N Weber, Astrid Becker, Dawid Eckert, Andreas Zimmer, Daniel Nettersheim, Hubert Schorle   +9 more
doaj   +1 more source

Postnatal germ cell development in cryptorchid boys

Asian Journal of Andrology, 2020
Cryptorchidism is associated with infertility in adulthood. Early orchiopexy is suggested to reduce the risk. Information is lacking on the potential link between infant germ cell maturation and the risk of future infertility.
Li-Hua Dong, Simone Hildorf, Erik Clasen-Linde, Kolja Kvist, Dina Cortes, Jørgen Thorup, Claus Yding Andersen   +6 more
doaj   +1 more source

Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

eLife, 2018
Germ granules are non-membranous ribonucleoprotein granules deemed the hubs for post-transcriptional gene regulation and functionally linked to germ cell fate across species.
Kathryn E Kistler, Tatjana Trcek, Thomas R Hurd, Ruoyu Chen, Feng-Xia Liang, Joseph Sall, Masato Kato, Ruth Lehmann   +7 more
doaj   +1 more source