Stem Cell Reports, 2017 In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRα1)-positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent
Moe Tokue +18 more
doaj +1 more source
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. [PDF]
PLoS ONE, 2014 The piRNA pathway plays an important role in maintaining genome stability in the germ line by silencing transposable elements (TEs) from fly to mammals.
Xing Ma +21 more
doaj +1 more source
DNA methylation and regulatory elements during chicken germline stem cell differentiation [PDF]
, 2018 Funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.The production of germ cells in vitro would open important new avenues for stem biology and human medicine, but the mechanisms of germ cell differentiation are not well ...
Cai, Wentao +8 more
core +2 more sources
Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin [PDF]
, 2008 Despite significant progress in identifying the guidance pathways that control cell migration, how a cell starts to move within an intact organism, acquires motility, and loses contact with its neighbors is poorly understood.
Barbosa, Vitor +5 more
core +3 more sources
piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm [PDF]
, 2017 Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine ...
Beilharz, Traude H. +9 more
core +4 more sources
A pilgrim's progress: Seeking meaning in primordial germ cell migration
Stem Cell Research, 2017 Comparative studies of primordial germ cell (PGC) development across organisms in many phyla reveal surprising diversity in the route of migration, timing and underlying molecular mechanisms, suggesting that the process of migration itself is conserved ...
Andrea V. Cantú, Diana J. Laird
doaj +1 more source
Mitotic arrest in teratoma susceptible fetal male germ cells. [PDF]
PLoS ONE, 2011 Formation of germ cell derived teratomas occurs in mice of the 129/SvJ strain, but not in C57Bl/6 inbred or CD1 outbred mice. Despite this, there have been few comparative studies aimed at determining the similarities and differences between teratoma ...
Patrick S Western +6 more
doaj +1 more source
Meiotic wave adds extra asymmetry to the development of female chicken gonads [PDF]
, 2015 Development of female gonads in the chicken is asymmetric. This asymmetry affects gene expression, morphology, and germ cell development; consequently only the left ovary develops into a functional organ, whereas the right ovary remains vestigial.
Anjie, Stafford +8 more
core +2 more sources
PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. [PDF]
, 2018 Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate.
Chen, Di +4 more
core +2 more sources
Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. [PDF]
PLoS ONE, 2016 The mechanisms underlying human germ cell development are largely unknown, partly due to the scarcity of primordial germ cells and the inaccessibility of the human germline to genetic analysis.
Sarita Panula +12 more
doaj +1 more source