Results 161 to 170 of about 11,695 (262)

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka   +9 more
wiley   +1 more source

Talin1 is downregulated in testicular germ cell tumors according to combined bioinformatics and experimental approaches. [PDF]

open access: yesSci Rep
Razmi M   +7 more
europepmc   +1 more source

Cancer Epidemiol Biomarkers Prev [PDF]

open access: yes
BackgroundTesticular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. In contrast to TGCT among infants, it is hypothesized that TGCT in adolescents and young men is the result of sex steroid hormone imbalance ...

core  

Clinical Features of Malignant Ovarian Germ Cell Tumors According to Demographic and Pathologic Characteristics

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Malignant ovarian germ cell tumors (MOGCTs) are aggressive cancers affecting mainly young women, in whom fertility preservation is important. Diagnosis is often delayed because early symptoms are non‐specific, leading to advanced disease or emergency surgery that may limit optimal staging and fertility‐sparing treatment. As
Jila Agah   +3 more
wiley   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao   +7 more
wiley   +1 more source

Second edition ICCR dataset for testicular germ cell tumours: a reporting guide for histopathological diagnosis of orchiectomy specimens. [PDF]

open access: yesHistopathology
Bremmer F   +12 more
europepmc   +1 more source

Replacement‐Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
We propose a roadmap to guide the development of rejuvenation therapeutics integrating replacement‐based ageing interventions, regeneration, and synthetic technologies that remove or export hundreds of types of molecular, organellar, and cellular damage.
Bjorn Fraser Olaisen   +12 more
wiley   +1 more source

Low-grade glial neoplasms of germ cell origin may represent maturation of embryonic-type neuroectodermal elements. [PDF]

open access: yesHistopathology
Lobo J   +10 more
europepmc   +1 more source

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